DHA-clozapine

Chemical compound
  • none
Legal statusLegal status
  • US: Investigational New Drug
Identifiers
  • (4Z,7Z,10Z,13Z,16Z,19Z)-1-[3-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzodiazepin-11-yl]docosa-4,7,10,13,16,19-hexaen-1-one
CAS Number
  • 225916-82-5 checkY
PubChem CID
  • 9852332
ChemSpider
  • 8028044 ☒N
UNII
  • Q5Q5VSN8DL
CompTox Dashboard (EPA)
  • DTXSID001027067 Edit this at Wikidata
Chemical and physical dataFormulaC40H49ClN4OMolar mass637.31 g·mol−13D model (JSmol)
  • Interactive image
  • Clc1ccc2N(C(=O)CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CC)c4ccccc4C(=N/c2c1)\N3CCN(C)CC3
InChI
  • InChI=1S/C40H49ClN4O/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-26-39(46)45-37-25-23-22-24-35(37)40(44-31-29-43(2)30-32-44)42-36-33-34(41)27-28-38(36)45/h4-5,7-8,10-11,13-14,16-17,19-20,22-25,27-28,33H,3,6,9,12,15,18,21,26,29-32H2,1-2H3/b5-4-,8-7-,11-10-,14-13-,17-16-,20-19- ☒N
  • Key:RPSJOJIGGSRDMO-JDPCYWKWSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

DHA-clozapine (tentative trade name Clozaprexin)[1] is an atypical antipsychotic drug candidate that was created and originally tested by chemists at Protarga, a small pharmaceutical in Pennsylvania, and scientists at Harvard University.[2]

It is a prodrug of clozapine; the fatty acid docosahexaenoic acid (DHA) was added to clozapine in order to increase penetration of the blood–brain barrier.[3]

Protarga was purchased by Luitpold Pharmaceuticals in 2003 and development was discontinued in 2007.[1]


References

  1. ^ a b "DHA-clozapine". AdisInsight. Retrieved 17 March 2017.
  2. ^ Rosack, Jim (4 May 2001). "Targaceuticals Point Way To Developing Safer Drugs". Psychiatric News. 36 (9): 36–37. doi:10.1176/pn.36.9.0036.
  3. ^ Baldessarini RJ, Campbell A, Webb NL, Swindell CS, Flood JG, Shashoua VE, et al. (January 2001). "Fatty acid derivatives of clozapine: prolonged antidopaminergic activity of docosahexaenoylclozapine in the rat". Neuropsychopharmacology. 24 (1): 55–65. doi:10.1016/S0893-133X(00)00173-1. PMID 11106876.
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