Chlorphenoxamine

Chemical compound
  • D04AA34 (WHO) R06AA06 (WHO)
Pharmacokinetic dataBioavailabilityWell absorbedMetabolismLikely liverExcretionkidneyIdentifiers
  • {2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl}dimethylamine
CAS Number
  • 77-38-3 checkY 562-09-4
PubChem CID
  • 6475
DrugBank
  • DB09007 ☒N
ChemSpider
  • 6230 checkY
UNII
  • 3UVD77BP8R
KEGG
  • D07198 checkY
ChEMBL
  • ChEMBL2110774 ☒N
CompTox Dashboard (EPA)
  • DTXSID5022805 Edit this at Wikidata
ECHA InfoCard100.115.538 Edit this at WikidataChemical and physical dataFormulaC18H22ClNOMolar mass303.83 g·mol−13D model (JSmol)
  • Interactive image
  • Clc1ccc(cc1)C(OCCN(C)C)(c2ccccc2)C
  • InChI=1S/C18H22ClNO/c1-18(21-14-13-20(2)3,15-7-5-4-6-8-15)16-9-11-17(19)12-10-16/h4-12H,13-14H2,1-3H3 checkY
  • Key:KKHPNPMTPORSQE-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Chlorphenoxamine (Phenoxene) is an antihistamine and anticholinergic used as an antipruritic[1] and antiparkinsonian[2] agent. It is an analog of diphenhydramine.[3]

References

  1. ^ Bazex A, Dupre A, Christol B (1963). "[Trial treatment of urticaria with chlorphenoxamine]". Clinique. 58: 447–50. PMID 13967113.
  2. ^ Uldall PR, Walton JN, Newell DJ (June 1961). "Chlorphenoxamine hydrochloride in parkinsonism. A controlled trial". British Medical Journal. 1 (5240): 1649–52. doi:10.1136/bmj.1.5240.1649. PMC 1954253. PMID 13779077.
  3. ^ Arnold H, Brock N, Kuhas E, Lorenz D (January 1954). "Beitrag Zur Wirkung Von Antihistamin-Substanzen. 1. Chemische Konstitution Und Pharmakologische Wirkung in Der Gruppe Der Basischen Benzhydrylaether" [Contribution to the Effect Of Antihistamine Substances. 1. Chemical constitution and pharmacological activity in the group of basic benzhydrylethers]. Arzneimittel-Forschung [Drug Research] (in German). 4 (3): 189–94. PMID 13159698.
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