SKF-97,541 je jedinjenje koje se koristi u naučnim istraživanjima, i koje je prvenstveno selektivni agonist GABAB receptora.[1] On ima sedativno ispoljava sedativno dejstvo u životinjskim studijama, i u širokoj je upotrebi u istraživanju potencijalnog tretmana za raznih tipove narkomanije.[2][3][4][5][6][7]
Reference
- ^ Seabrook GR, Howson W, Lacey MG (1990). „Electrophysiological characterization of potent agonists and antagonists at pre- and postsynaptic GABAB receptors on neurones in rat brain slices”. British Journal of Pharmacology. 101 (4): 949—57. PMC 1917862
. PMID 1964824. - ^ Jackson GL, Kuehl D (2002). „The GABA(B) antagonist CGP 52432 attenuates the stimulatory effect of the GABA(B) agonist SKF 97541 on luteinizing hormone secretion in the male sheep”. Experimental Biology and Medicine (Maywood, N.J.). 227 (5): 315—20. PMID 11976401.
- ^ Besheer J, Lepoutre V, Hodge CW (2004). „GABA(B) receptor agonists reduce operant ethanol self-administration and enhance ethanol sedation in C57BL/6J mice”. Psychopharmacology. 174 (3): 358—66. PMID 14985930. doi:10.1007/s00213-003-1769-3.
- ^ Carter LP, Chen W, Coop A, Koek W, France CP (2006). „Discriminative stimulus effects of GHB and GABA(B) agonists are differentially attenuated by CGP35348”. European Journal of Pharmacology. 538 (1-3): 85—93. PMID 16647701. doi:10.1016/j.ejphar.2006.03.039.
- ^ Koek W, Mercer SL, Coop A (2007). „Cataleptic effects of gamma-hydroxybutyrate (GHB), its precursor gamma-butyrolactone (GBL), and GABAB receptor agonists in mice: differential antagonism by the GABAB receptor antagonist CGP35348”. Psychopharmacology. 192 (3): 407—14. PMID 17277933. doi:10.1007/s00213-007-0718-y.
- ^ Koek W, Mercer SL, Coop A, France CP (2009). „Behavioral effects of gamma-hydroxybutyrate, its precursor gamma-butyrolactone, and GABA(B) receptor agonists: time course and differential antagonism by the GABA(B) receptor antagonist 3-aminopropyl(diethoxymethyl)phosphinic acid (CGP35348)”. The Journal of Pharmacology and Experimental Therapeutics. 330 (3): 876—83. PMID 19564487. doi:10.1124/jpet.109.151845.
- ^ Frankowska M, Nowak E, Filip M (2009). „Effects of GABAB receptor agonists on cocaine hyperlocomotor and sensitizing effects in rats”. Pharmacological Reports : PR. 61 (6): 1042—9. PMID 20081239.
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