MAPK10

Protein-coding gene in the species Homo sapiens
MAPK10
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1JNK, 1PMN, 1PMU, 1PMV, 2B1P, 2EXC, 2O0U, 2O2U, 2OK1, 2P33, 2R9S, 2WAJ, 2ZDT, 2ZDU, 3CGF, 3CGO, 3DA6, 3FI2, 3FI3, 3FV8, 3G90, 3G9L, 3G9N, 3KVX, 3OXI, 3OY1, 3PTG, 3RTP, 3TTI, 3TTJ, 3V6R, 3V6S, 4H36, 4H39, 4H3B, 4KKG, 4KKH, 4U79, 4W4V, 4W4W, 4W4X, 4W4Y, 4WHZ, 4Y46, 4Y5H, 4Z9L, 4X21

Identifiers
AliasesMAPK10, JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK, mitogen-activated protein kinase 10
External IDsOMIM: 602897; MGI: 1346863; HomoloGene: 56439; GeneCards: MAPK10; OMA:MAPK10 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for MAPK10
Genomic location for MAPK10
Band4q21.3Start85,990,007 bp[1]
End86,594,625 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for MAPK10
Genomic location for MAPK10
Band5|5 E5Start103,055,814 bp[2]
End103,359,200 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • prefrontal cortex

  • right frontal lobe

  • Brodmann area 9

  • primary visual cortex

  • middle temporal gyrus

  • Brodmann area 23

  • cingulate gyrus

  • anterior cingulate cortex

  • endothelial cell

  • frontal pole
Top expressed in
  • substantia nigra

  • motor neuron

  • medial vestibular nucleus

  • subiculum

  • medial geniculate nucleus

  • prefrontal cortex

  • medial dorsal nucleus

  • primary motor cortex

  • mammillary body

  • lateral geniculate nucleus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • nucleotide binding
  • protein kinase activity
  • MAP kinase activity
  • kinase activity
  • protein serine/threonine kinase activity
  • protein binding
  • ATP binding
  • MAP kinase kinase activity
  • JUN kinase activity
Cellular component
  • cytosol
  • membrane
  • mitochondrion
  • plasma membrane
  • nucleus
  • cytoplasm
  • neuron projection
  • nucleoplasm
  • perikaryon
  • glutamatergic synapse
  • intracellular anatomical structure
Biological process
  • phosphorylation
  • response to light stimulus
  • rhythmic process
  • Fc-epsilon receptor signaling pathway
  • protein phosphorylation
  • regulation of circadian rhythm
  • signal transduction
  • JUN phosphorylation
  • JNK cascade
  • regulation of gene expression
  • neuron development
  • intracellular signal transduction
  • cellular response to organic substance
  • negative regulation of transcription by RNA polymerase II
  • response to water deprivation
  • cellular hyperosmotic response
  • neurotransmitter receptor transport to postsynaptic membrane
  • vesicle-mediated transport in synapse
  • regulation of DNA-binding transcription factor activity
  • MAPK cascade
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5602

26414

Ensembl

ENSG00000109339

ENSMUSG00000046709

UniProt

P53779
Q499Y8

Q61831

RefSeq (mRNA)
NM_002753
NM_138980
NM_138981
NM_138982
NM_001318067

NM_001318068
NM_001318069
NM_001351624
NM_001351625
NM_001363657

NM_001081567
NM_009158
NM_001310683
NM_001310685
NM_001310686

NM_001318102
NM_001318131

RefSeq (protein)
NP_001304996
NP_001304997
NP_001304998
NP_002744
NP_620446

NP_620448
NP_001338553
NP_001338554
NP_001350586
NP_001304997.1

NP_001075036
NP_001297612
NP_001297614
NP_001297615
NP_001305031

NP_001305060
NP_033184
NP_001394501
NP_001394502
NP_001394503
NP_001394504
NP_001394505
NP_001394506
NP_001394507
NP_001394508
NP_001394509
NP_001394513
NP_001394515
NP_001394517
NP_001394518
NP_001394521
NP_001394524
NP_001394528
NP_001394529
NP_001394530

Location (UCSC)Chr 4: 85.99 – 86.59 MbChr 5: 103.06 – 103.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mitogen-activated protein kinase 10 also known as c-Jun N-terminal kinase 3 (JNK3) is an enzyme that in humans is encoded by the MAPK10 gene.[5][6][7]

Function

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kinase 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.[7]

Interactions

MAPK10 has been shown to interact with MAPK8IP3.[8][9][10]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000109339 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046709 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gupta S, Barrett T, Whitmarsh AJ, Cavanagh J, Sluss HK, Dérijard B, Davis RJ (July 1996). "Selective interaction of JNK protein kinase isoforms with transcription factors". EMBO J. 15 (11): 2760–70. doi:10.1002/j.1460-2075.1996.tb00636.x. PMC 450211. PMID 8654373.
  6. ^ Yoshida S, Harada H, Nagai H, Fukino K, Teramoto A, Emi M (November 2002). "Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1) and c-Jun NH2-terminal kinase 3 (JNK3) genes: genomic structure and seven polymorphisms of the FAP-1 gene". J. Hum. Genet. 47 (11): 614–9. doi:10.1007/s100380200094. PMID 12436199.
  7. ^ a b "Entrez Gene: MAPK10 mitogen-activated protein kinase 10".
  8. ^ Ito M, Yoshioka K, Akechi M, Yamashita S, Takamatsu N, Sugiyama K, Hibi M, Nakabeppu Y, Shiba T, Yamamoto KI (November 1999). "JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway". Mol. Cell. Biol. 19 (11): 7539–48. doi:10.1128/mcb.19.11.7539. PMC 84763. PMID 10523642.
  9. ^ Kelkar N, Gupta S, Dickens M, Davis RJ (February 2000). "Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3". Mol. Cell. Biol. 20 (3): 1030–43. doi:10.1128/MCB.20.3.1030-1043.2000. PMC 85220. PMID 10629060.
  10. ^ Matsuura H, Nishitoh H, Takeda K, Matsuzawa A, Amagasa T, Ito M, Yoshioka K, Ichijo H (October 2002). "Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade". J. Biol. Chem. 277 (43): 40703–9. doi:10.1074/jbc.M202004200. hdl:2297/2692. PMID 12189133.

Further reading

  • Freedman BD, Liu QH, Del Corno M, Collman RG (2003). "HIV-1 gp120 chemokine receptor-mediated signaling in human macrophages". Immunol. Res. 27 (2–3): 261–76. doi:10.1385/IR:27:2-3:261. PMID 12857973. S2CID 32006625.
  • Lee C, Liu QH, Tomkowicz B, Yi Y, Freedman BD, Collman RG (2003). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". J. Leukoc. Biol. 74 (5): 676–82. doi:10.1189/jlb.0503206. PMID 12960231. S2CID 11362623.
  • Pulverer BJ, Kyriakis JM, Avruch J, Nikolakaki E, Woodgett JR (1991). "Phosphorylation of c-jun mediated by MAP kinases". Nature. 353 (6345): 670–4. Bibcode:1991Natur.353..670P. doi:10.1038/353670a0. PMID 1922387. S2CID 29557176.
  • Mohit AA, Martin JH, Miller CA (1995). "p493F12 kinase: a novel MAP kinase expressed in a subset of neurons in the human nervous system". Neuron. 14 (1): 67–78. doi:10.1016/0896-6273(95)90241-4. PMID 7826642. S2CID 14107133.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Jabado N, Pallier A, Jauliac S, Fischer A, Hivroz C (1997). "gp160 of HIV or anti-CD4 monoclonal antibody ligation of CD4 induces inhibition of JNK and ERK-2 activities in human peripheral CD4+ T lymphocytes". Eur. J. Immunol. 27 (2): 397–404. doi:10.1002/eji.1830270209. PMID 9045910. S2CID 23787450.
  • Yang DD, Kuan CY, Whitmarsh AJ, Rincón M, Zheng TS, Davis RJ, Rakic P, Flavell RA (1997). "Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene". Nature. 389 (6653): 865–70. Bibcode:1997Natur.389..865Y. doi:10.1038/39899. PMID 9349820. S2CID 4430535.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Hu MC, Qiu WR, Wang YP (1997). "JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases". Oncogene. 15 (19): 2277–87. doi:10.1038/sj.onc.1201401. PMID 9393873.
  • Lannuzel A, Barnier JV, Hery C, Huynh VT, Guibert B, Gray F, Vincent JD, Tardieu M (1997). "Human immunodeficiency virus type 1 and its coat protein gp120 induce apoptosis and activate JNK and ERK mitogen-activated protein kinases in human neurons". Ann. Neurol. 42 (6): 847–56. doi:10.1002/ana.410420605. PMID 9403476. S2CID 36951375.
  • Xie X, Gu Y, Fox T, Coll JT, Fleming MA, Markland W, Caron PR, Wilson KP, Su MS (1998). "Crystal structure of JNK3: a kinase implicated in neuronal apoptosis". Structure. 6 (8): 983–91. doi:10.1016/S0969-2126(98)00100-2. PMID 9739089.
  • Sanger Centre, The; Washington University Genome Sequencing Cente, The (1998). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
  • Koyano S, Ito M, Takamatsu N, Shiba T, Yamamoto K, Yoshioka K (1999). "A novel Jun N-terminal kinase (JNK)-binding protein that enhances the activation of JNK by MEK kinase 1 and TGF-beta-activated kinase 1". FEBS Lett. 457 (3): 385–8. doi:10.1016/S0014-5793(99)01084-4. PMID 10471813. S2CID 32690852.
  • Ito M, Yoshioka K, Akechi M, Yamashita S, Takamatsu N, Sugiyama K, Hibi M, Nakabeppu Y, Shiba T, Yamamoto KI (1999). "JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway". Mol. Cell. Biol. 19 (11): 7539–48. doi:10.1128/mcb.19.11.7539. PMC 84763. PMID 10523642.
  • Kelkar N, Gupta S, Dickens M, Davis RJ (2000). "Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3". Mol. Cell. Biol. 20 (3): 1030–43. doi:10.1128/MCB.20.3.1030-1043.2000. PMC 85220. PMID 10629060.
  • Lisnock J, Griffin P, Calaycay J, Frantz B, Parsons J, O'Keefe SJ, LoGrasso P (2000). "Activation of JNK3 alpha 1 requires both MKK4 and MKK7: kinetic characterization of in vitro phosphorylated JNK3 alpha 1". Biochemistry. 39 (11): 3141–8. doi:10.1021/bi992410. PMID 10715136.
  • McDonald PH, Chow CW, Miller WE, Laporte SA, Field ME, Lin FT, Davis RJ, Lefkowitz RJ (2000). "Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3". Science. 290 (5496): 1574–7. Bibcode:2000Sci...290.1574M. doi:10.1126/science.290.5496.1574. PMID 11090355.
  • Pouysségur J (2000). "Signal transduction. An arresting start for MAPK". Science. 290 (5496): 1515–8. doi:10.1126/science.290.5496.1515. PMID 11185509. S2CID 84778351.
  • Habelhah H, Shah K, Huang L, Ostareck-Lederer A, Burlingame AL, Shokat KM, Hentze MW, Ronai Z (2001). "ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation". Nat. Cell Biol. 3 (3): 325–30. doi:10.1038/35060131. PMID 11231586. S2CID 34298842.

External links

  • MAP Kinase Resource Archived 2021-04-15 at the Wayback Machine.
  • Overview of all the structural information available in the PDB for UniProt: P53779 (Mitogen-activated protein kinase 10) at the PDBe-KB.
  • v
  • t
  • e
  • 1jnk: THE C-JUN N-TERMINAL KINASE (JNK3S) COMPLEXED WITH MGAMP-PNP
    1jnk: THE C-JUN N-TERMINAL KINASE (JNK3S) COMPLEXED WITH MGAMP-PNP
  • 1pmn: Crystal structure of JNK3 in complex with an imidazole-pyrimidine inhibitor
    1pmn: Crystal structure of JNK3 in complex with an imidazole-pyrimidine inhibitor
  • 1pmq: The structure of JNK3 in complex with an imidazole-pyrimidine inhibitor
    1pmq: The structure of JNK3 in complex with an imidazole-pyrimidine inhibitor
  • 1pmu: The crystal structure of JNK3 in complex with a phenantroline inhibitor
    1pmu: The crystal structure of JNK3 in complex with a phenantroline inhibitor
  • 1pmv: The structure of JNK3 in complex with a dihydroanthrapyrazole inhibitor
    1pmv: The structure of JNK3 in complex with a dihydroanthrapyrazole inhibitor
  • 1ukh: Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125
    1ukh: Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125
  • 1uki: Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125
    1uki: Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125
  • 2b1p: inhibitor complex of JNK3
    2b1p: inhibitor complex of JNK3
  • 2exc: Inhibitor complex of JNK3
    2exc: Inhibitor complex of JNK3
  • 2g01: Pyrazoloquinolones as Novel, Selective JNK1 inhibitors
    2g01: Pyrazoloquinolones as Novel, Selective JNK1 inhibitors
  • 2gmx: Selective Aminopyridine-Based C-Jun N-terminal Kinase inhibitors with cellular activity
    2gmx: Selective Aminopyridine-Based C-Jun N-terminal Kinase inhibitors with cellular activity
  • 2h96: Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide C-jun NH2-terminal Kinase Inhibitors
    2h96: Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide C-jun NH2-terminal Kinase Inhibitors
  • 2no3: Novel 4-anilinopyrimidines as potent JNK1 Inhibitors
    2no3: Novel 4-anilinopyrimidines as potent JNK1 Inhibitors
  • 2o0u: Crystal structure of human JNK3 complexed with N-{3-cyano-6-[3-(1-piperidinyl)propanoyl]-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl}-1-naphthalenecarboxamide
    2o0u: Crystal structure of human JNK3 complexed with N-{3-cyano-6-[3-(1-piperidinyl)propanoyl]-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl}-1-naphthalenecarboxamide
  • 2o2u: Crystal structure of human JNK3 complexed with N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide
    2o2u: Crystal structure of human JNK3 complexed with N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide
  • 2ok1: Crystal structure of JNK3 bound to N-benzyl-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide
    2ok1: Crystal structure of JNK3 bound to N-benzyl-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide
  • v
  • t
  • e
Non-specific serine/threonine protein kinases (EC 2.7.11.1)
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
Myosin-heavy-chain kinase (EC 2.7.11.7)
Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
  • -
IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
cGMP-dependent protein kinase (EC 2.7.11.12)
Protein kinase C (EC 2.7.11.13)
Rhodopsin kinase (EC 2.7.11.14)
Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
Myosin light-chain kinase (EC 2.7.11.18)
Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
  • -
Tropomyosin kinase (EC 2.7.11.28)
  • -
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
  • -
Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K
Portal:
  • icon Biology


Stub icon

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e