MAP3K9

Protein-coding gene in the species Homo sapiens
MAP3K9
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3DTC, 4UY9

Identifiers
AliasesMAP3K9, MEKK9, MLK1, PRKE1, mitogen-activated protein kinase kinase kinase 9
External IDsOMIM: 600136; MGI: 2449952; HomoloGene: 76377; GeneCards: MAP3K9; OMA:MAP3K9 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for MAP3K9
Genomic location for MAP3K9
Band14q24.2Start70,722,526 bp[1]
End70,809,534 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for MAP3K9
Genomic location for MAP3K9
Band12|12 D1Start81,767,784 bp[2]
End81,827,949 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • lateral nuclear group of thalamus

  • cerebellar vermis

  • Pars compacta

  • frontal pole

  • postcentral gyrus

  • amniotic fluid

  • pars reticulata

  • orbitofrontal cortex

  • middle temporal gyrus
Top expressed in
  • superior frontal gyrus

  • lip

  • esophagus

  • cerebellar cortex

  • yolk sac

  • secondary oocyte

  • morula

  • stomach

  • neural tube

  • ganglionic eminence
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • nucleotide binding
  • protein kinase activity
  • protein homodimerization activity
  • kinase activity
  • protein serine/threonine kinase activity
  • protein binding
  • ATP binding
  • MAP kinase kinase kinase activity
  • MAP kinase kinase activity
  • JUN kinase kinase kinase activity
Cellular component
  • cytoplasm
  • cellular component
  • intracellular anatomical structure
Biological process
  • regulation of transcription, DNA-templated
  • phosphorylation
  • cell death
  • transcription, DNA-templated
  • protein phosphorylation
  • positive regulation of apoptotic process
  • protein autophosphorylation
  • apoptotic process
  • MAPK cascade
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4293

338372

Ensembl

ENSG00000006432

ENSMUSG00000042724

UniProt

P80192

Q3U1V8

RefSeq (mRNA)

NM_001284230
NM_001284231
NM_001284232
NM_033141

NM_001174107
NM_177395

RefSeq (protein)

NP_001271159
NP_001271160
NP_001271161
NP_149132

NP_001167578
NP_796369

Location (UCSC)Chr 14: 70.72 – 70.81 MbChr 12: 81.77 – 81.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mitogen-activated protein kinase kinase kinase 9 is an enzyme that in humans is encoded by the MAP3K9 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000006432 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042724 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: MAP3K9 mitogen-activated protein kinase kinase kinase 9".

Further reading

  • Gallo KA, Mark MR, Scadden DT, et al. (1994). "Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity". J. Biol. Chem. 269 (21): 15092–100. doi:10.1016/S0021-9258(17)36578-X. PMID 8195146.
  • Dorow DS, Devereux L, Dietzsch E, De Kretser T (1993). "Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains". Eur. J. Biochem. 213 (2): 701–10. doi:10.1111/j.1432-1033.1993.tb17810.x. PMID 8477742.
  • Dorow DS, Devereux L, Tu GF, et al. (1996). "Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2". Eur. J. Biochem. 234 (2): 492–500. doi:10.1111/j.1432-1033.1995.492_b.x. PMID 8536694.
  • Xu Z, Maroney AC, Dobrzanski P, et al. (2001). "The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis". Mol. Cell. Biol. 21 (14): 4713–24. doi:10.1128/MCB.21.14.4713-4724.2001. PMC 87148. PMID 11416147.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Figueroa C, Tarras S, Taylor J, Vojtek AB (2004). "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex". J. Biol. Chem. 278 (48): 47922–7. doi:10.1074/jbc.M307357200. PMID 14504284.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Durkin JT, Holskin BP, Kopec KK, et al. (2005). "Phosphoregulation of mixed-lineage kinase 1 activity by multiple phosphorylation in the activation loop". Biochemistry. 43 (51): 16348–55. doi:10.1021/bi049866y. PMID 15610029.

External links

  • Overview of all the structural information available in the PDB for UniProt: P80192 (Mitogen-activated protein kinase kinase kinase 9) at the PDBe-KB.
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Non-specific serine/threonine protein kinases (EC 2.7.11.1)
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
Myosin-heavy-chain kinase (EC 2.7.11.7)
Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
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IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
cGMP-dependent protein kinase (EC 2.7.11.12)
Protein kinase C (EC 2.7.11.13)
Rhodopsin kinase (EC 2.7.11.14)
Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
Myosin light-chain kinase (EC 2.7.11.18)
Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
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Tropomyosin kinase (EC 2.7.11.28)
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Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
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Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K
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