Hemoglobin, alpha 2

Mammalian protein found in Homo sapiens
HBA2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1A00, 1A01, 1A0U, 1A0Z, 1A3N, 1A3O, 1A9W, 1ABW, 1ABY, 1AJ9, 1B86, 1BAB, 1BBB, 1BIJ, 1BUW, 1BZ0, 1BZ1, 1BZZ, 1C7B, 1C7C, 1C7D, 1CLS, 1CMY, 1COH, 1DKE, 1DXT, 1DXU, 1DXV, 1FDH, 1FN3, 1G9V, 1GBU, 1GBV, 1GLI, 1GZX, 1HAB, 1HAC, 1HBA, 1HBB, 1HBS, 1HCO, 1HDB, 1HGA, 1HGB, 1HGC, 1HHO, 1IRD, 1J3Y, 1J3Z, 1J40, 1J41, 1J7S, 1J7W, 1J7Y, 1JY7, 1K0Y, 1K1K, 1KD2, 1LFL, 1LFQ, 1LFT, 1LFV, 1LFY, 1LFZ, 1LJW, 1M9P, 1MKO, 1NEJ, 1NIH, 1NQP, 1O1I, 1O1J, 1O1K, 1O1L, 1O1M, 1O1N, 1O1O, 1O1P, 1QI8, 1QSH, 1QSI, 1QXD, 1QXE, 1R1X, 1R1Y, 1RPS, 1RQ3, 1RQ4, 1RQA, 1RVW, 1SDK, 1SDL, 1SHR, 1SI4, 1THB, 1UIW, 1VWT, 1XXT, 1XY0, 1XYE, 1XZ2, 1XZ4, 1XZ5, 1XZ7, 1XZU, 1XZV, 1Y01, 1Y09, 1Y0A, 1Y0C, 1Y0D, 1Y0T, 1Y0W, 1Y22, 1Y2Z, 1Y31, 1Y35, 1Y45, 1Y46, 1Y4B, 1Y4F, 1Y4G, 1Y4P, 1Y4Q, 1Y4R, 1Y4V, 1Y5F, 1Y5J, 1Y5K, 1Y7C, 1Y7D, 1Y7G, 1Y7Z, 1Y83, 1Y85, 1Y8W, 1YDZ, 1YE0, 1YE1, 1YE2, 1YEN, 1YEO, 1YEQ, 1YEU, 1YEV, 1YFF, 1YG5, 1YGD, 1YGF, 1YH9, 1YHE, 1YHR, 1YIE, 1YIH, 1YVQ, 1YVT, 1YZI, 1Z8U, 2D5Z, 2D60, 2DN1, 2DN2, 2DN3, 2DXM, 2H35, 2HBC, 2HBD, 2HBE, 2HBF, 2HBS, 2HCO, 2HHD, 2HHE, 2M6Z, 2W6V, 2W72, 2YRS, 3B75, 3D17, 3D7O, 3DUT, 3HXN, 3IA3, 3IC0, 3IC2, 3KMF, 3NL7, 3NMM, 3ODQ, 3ONZ, 3OO4, 3OO5, 3OVU, 3P5Q, 3QJB, 3QJC, 3QJD, 3QJE, 3R5I, 3S48, 3S65, 3S66, 3SZK, 3WCP, 3WHM, 4FC3, 4HHB, 4IJ2, 4L7Y, 4M4A, 4M4B, 4MQC, 4MQG, 4MQH, 4MQI, 4MQJ, 4MQK, 4N7N, 4N7O, 4N7P, 4N8T, 4NI0, 4NI1, 4ROL, 4ROM, 4WJG, 4X0L, 4XS0, 6HBW, 5E29, 5E6E, 5EE4, 5HU6, 5JDO, 5KDQ, 5E83,%%s1Y01, 1Z8U, 1BZ1

Identifiers
AliasesHBA2, HBA-T2, HBH, Hemoglobin, alpha 2, hemoglobin subunit alpha 2, ECYT7
External IDsOMIM: 141850 MGI: 96015 HomoloGene: 469 GeneCards: HBA2
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for HBA2
Genomic location for HBA2
Band16p13.3Start172,876 bp[1]
End173,710 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for HBA2
Genomic location for HBA2
Band11 A4|11 18.86 cMStart32,233,511 bp[2]
End32,234,465 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • monocyte

  • blood

  • bone marrow

  • bone marrow cells

  • placenta

  • spleen

  • ganglionic eminence

  • upper lobe of left lung

  • amygdala

  • substantia nigra
Top expressed in
  • bone marrow

  • spleen

  • lung

  • yolk sac

  • neural tube

  • mesencephalon

  • heart

  • cerebellar cortex

  • zone of skin

  • adrenal gland
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • iron ion binding
  • oxygen binding
  • peroxidase activity
  • oxygen carrier activity
  • metal ion binding
  • protein binding
  • heme binding
  • haptoglobin binding
  • organic acid binding
Cellular component
  • cytosol
  • endocytic vesicle lumen
  • blood microparticle
  • membrane
  • extracellular region
  • cytosolic small ribosomal subunit
  • hemoglobin complex
  • extracellular exosome
  • haptoglobin-hemoglobin complex
  • extracellular space
Biological process
  • positive regulation of cell death
  • protein heterooligomerization
  • oxygen transport
  • receptor-mediated endocytosis
  • bicarbonate transport
  • hydrogen peroxide catabolic process
  • response to hydrogen peroxide
  • cellular oxidant detoxification
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3040

15122

Ensembl

ENSG00000188536

ENSMUSG00000069919

UniProt

P69905

Q91VB8

RefSeq (mRNA)

NM_000517

NM_008218

RefSeq (protein)

NP_000508
NP_000508.1
NP_000549.1

NP_001077424

Location (UCSC)Chr 16: 0.17 – 0.17 MbChr 11: 32.23 – 32.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Hemoglobin, alpha 2[5] also known as HBA2 is a gene that in humans codes for the alpha globin chain of hemoglobin.[6][7]

Function

The human alpha globin gene cluster is located on chromosome 16 and spans about 30 kb, including seven alpha like globin genes and pseudogenes: 5'- HBZ - HBZP1 - HBM - HBAP1 - HBA2 - HBA1 - HBQ1 -3'. The HBA2 (α2) and HBA1 (α1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions.

Protein

Two alpha chains plus two beta chains constitute HbA, which in normal adult life accounts for about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin), composed of alpha and gamma chains, make up the remaining 3% of adult hemoglobin.

Clinical significance

Alpha-thalassemias most commonly result from deletions of any of the four alpha alleles, although some alpha thalassemias have been reported that are due to mutations other than deletion. Deletion of 1 or 2 alleles is clinically silent. Deletion of 3 alleles causes HbH disease, resulting in anemia and hepatosplenomegaly. Deletion of all 4 alleles is lethal because it renders the body unable to make fetal hemoglobin (HbF), adult hemoglobin (HbA) or adult variant hemoglobin (HbA2), and results in hydrops fetalis.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000188536 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000069919 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "HBA2 gene: MedlinePlus Genetics".
  6. ^ Liebhaber SA, Goossens MJ, Kan YW (Dec 1980). "Cloning and complete nucleotide sequence of human 5'-alpha-globin gene". Proceedings of the National Academy of Sciences of the United States of America. 77 (12): 7054–8. Bibcode:1980PNAS...77.7054L. doi:10.1073/pnas.77.12.7054. PMC 350439. PMID 6452630.
  7. ^ Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (Apr 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood. 73 (5): 1081–104. doi:10.1182/blood.V73.5.1081.1081. PMID 2649166.
  8. ^ "Entrez Gene: HBA2 hemoglobin, alpha 2".

Further reading

  • Richter F, Meurers BH, Zhu C, Medvedeva VP, Chesselet MF (Aug 2009). "Neurons express hemoglobin alpha- and beta-chains in rat and human brains". The Journal of Comparative Neurology. 515 (5): 538–47. doi:10.1002/cne.22062. PMC 3123135. PMID 19479992.
  • Phylipsen M, Vogelaar IP, Schaap RA, Arkesteijn SG, Boxma GL, van Helden WC, Wildschut IC, de Bruin-Roest AC, Giordano PC, Harteveld CL (Aug 2010). "A new alpha(0)-thalassemia deletion found in a Dutch family (--(AW))". Blood Cells, Molecules & Diseases. 45 (2): 133–5. doi:10.1016/j.bcmd.2010.05.004. PMID 20682466.
  • Sessa R, Puzone S, Ammirabile M, Piscopo C, Pagano L, Colucci S, Izzo P, Grosso M (Feb 2010). "Identification and molecular characterization of the --CAMPANIA deletion, a novel alpha (0) -thalassemic defect, in two unrelated Italian families [corrected]". American Journal of Hematology. 85 (2): 143–4. doi:10.1002/ajh.21591. PMID 20054848. S2CID 26190193.
  • Yin XL, Zhang XH, Zhou TH, Zhang TL, Luo RG, Wang L, Zhou YL, Chen YS, Kong XJ, Liang B, He YY, Peng L, Lu LB, Fang SP, Wu ZK (2010). "Hemoglobin H disease in Guangxi province, Southern China: clinical review of 357 patients". Acta Haematologica. 124 (2): 86–91. doi:10.1159/000314058. PMID 20639625. S2CID 38841342.
  • Joly P, Lacan P, Bererd M, Garcia C, Zanella-Cleon I, Becchi M, Aubry M, Couprie N, Francina A (2009). "Description of two new alpha variants: Hb Canuts [alpha85(F6)Asp-->His (alpha1)] and Hb Ambroise Pare [alpha117(GH5)Phe-->Ile (alpha2)]; two new beta variants: Hb Beaujolais [beta84(EF8)Thr-->Asn] and Hb Monplaisir [beta147 (Tyr-Lys-Leu-Ala-Phe-Phe-Leu-Leu-Ser-Asn-Phe-Tyr-158-COOH)] and one new delta variant: Hb (A2)North Africa [delta59(E3)Lys-->Met]". Hemoglobin. 33 (3): 196–205. doi:10.1080/03630260903058685. PMID 19657833. S2CID 26959240.
  • Harteveld CL, Oosterhuis WP, Schoenmakers CH, Ananta H, Kos S, Bakker Verweij M, van Delft P, Arkesteijn SG, Phylipsen M, Giordano PC (Apr 2010). "alpha-thalassaemia masked by beta gene defects and a new polyadenylation site mutation on the alpha2-globin gene". European Journal of Haematology. 84 (4): 354–8. doi:10.1111/j.1600-0609.2009.01380.x. PMID 19912309. S2CID 20511683.
  • Kapralov A, Vlasova II, Feng W, Maeda A, Walson K, Tyurin VA, Huang Z, Aneja RK, Carcillo J, Bayir H, Kagan VE (Oct 2009). "Peroxidase activity of hemoglobin-haptoglobin complexes: covalent aggregation and oxidative stress in plasma and macrophages". The Journal of Biological Chemistry. 284 (44): 30395–407. doi:10.1074/jbc.M109.045567. PMC 2781594. PMID 19740759.
  • Roy P, Bhattacharya G, Banerjee D, Chandra S, Ghosh M, Choudhuri U, Das M, Dasgupta UB (2009). "Hb Sallanches [alpha104(G11)Cys-->Tyr, TGC>TAC] occurs frequently on the Indian subcontinent". Hemoglobin. 33 (6): 486–91. doi:10.3109/03630260903336164. PMID 19958194. S2CID 22370275.
  • Giardina B, Messana I, Scatena R, Castagnola M (1995). "The multiple functions of hemoglobin". Critical Reviews in Biochemistry and Molecular Biology. 30 (3): 165–96. doi:10.3109/10409239509085142. PMID 7555018.
  • Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (Apr 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood. 73 (5): 1081–104. doi:10.1182/blood.V73.5.1081.1081. PMID 2649166.
  • Ribeiro DM, Sonati MF (2008). "Regulation of human alpha-globin gene expression and alpha-thalassemia". Genetics and Molecular Research. 7 (4): 1045–53. doi:10.4238/vol7-4gmr472. PMID 19048483.
  • Waye JS, Eng B, Dutly F, Frischknecht H (2009). "alpha-Thalassemia caused by two novel splice mutations of the alpha2-globin gene: IVS-I-1 (G>A and G>T)". Hemoglobin. 33 (6): 519–22. doi:10.3109/03630260903333377. PMID 19958200. S2CID 41033036.
  • Coelho A, Picanço I, Seuanes F, Seixas MT, Faustino P (Aug 2010). "Novel large deletions in the human alpha-globin gene cluster: Clarifying the HS-40 long-range regulatory role in the native chromosome environment" (PDF). Blood Cells, Molecules & Diseases. 45 (2): 147–53. doi:10.1016/j.bcmd.2010.05.010. hdl:10400.18/117. PMID 20580289.
  • Sharma V, Kumar B, Kumar G, Saxena R (Oct 2009). "Alpha globin gene numbers: an important modifier of HbE/beta thalassemia". Hematology. 14 (5): 297–300. doi:10.1179/102453309X446126. PMID 19843387. S2CID 11461489.
  • Turbpaiboon C, Wilairat P (2010). "Alpha-hemoglobin stabilizing protein: molecular function and clinical correlation". Frontiers in Bioscience. 15 (1): 1–11. doi:10.2741/3601. PMID 20036801.
  • Voon HP, Vadolas J (Dec 2008). "Controlling alpha-globin: a review of alpha-globin expression and its impact on beta-thalassemia". Haematologica. 93 (12): 1868–76. doi:10.3324/haematol.13490. PMID 18768527.
  • Giordano PC, Cnossen MH, Joosten AM, Jansen CA, Hakvoort TE, Bakker-Verweij M, Arkesteijn SG, van Delft P, Waye JS, Bouva MJ, Harteveld CL (2010). "Codon 24 (TAT>TAG) and codon 32 (ATG>AGG) (Hb Rotterdam): two novel alpha2 gene mutations associated with mild alpha-thalassemia found in the same family after newborn screening". Hemoglobin. 34 (4): 354–65. doi:10.3109/03630269.2010.486341. PMID 20642333. S2CID 35413104.
  • Mahdavi MR, Kowsarian M, Karami H, Mohseni A, Vahidshahi K, Roshan P, Hojjati MT, Ebrahimzadeh MA (Oct 2010). "Prevalence of hemoglobin alpha-chain gene deletion in neonates in North of Iran". European Review for Medical and Pharmacological Sciences. 14 (10): 871–5. PMID 21222374.
  • Balakrishnan G, Zhao X, Podstawska E, Proniewicz LM, Kincaid JR, Spiro TG (Apr 2009). "Subunit-selective interrogation of CO recombination in carbonmonoxy hemoglobin by isotope-edited time-resolved resonance Raman spectroscopy". Biochemistry. 48 (14): 3120–6. doi:10.1021/bi802190f. PMC 2722936. PMID 19245215.
  • Zhu C, Yu W, Xie J, Chen L, Ding H, Shang X, Xu X (Oct 2010). "Hemoglobin H disease due to a de novo mutation at the α2-globin gene and an inherited common α-thalassemia deletion found in a Chinese boy". Blood Cells, Molecules & Diseases. 45 (3): 223–6. doi:10.1016/j.bcmd.2010.07.005. PMID 20691621.

External links

  • GeneReviews/NCBI/NIH/UW entry on Alpha-Thalassemia
  • OMIM entries on Alpha-Thalassemia

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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  • 1hbb: HIGH-RESOLUTION X-RAY STUDY OF DEOXYHEMOGLOBIN ROTHSCHILD 37BETA TRP-> ARG: A MUTATION THAT CREATES AN INTERSUBUNIT CHLORIDE-BINDING SITE
    1hbb: HIGH-RESOLUTION X-RAY STUDY OF DEOXYHEMOGLOBIN ROTHSCHILD 37BETA TRP-> ARG: A MUTATION THAT CREATES AN INTERSUBUNIT CHLORIDE-BINDING SITE
  • 1ye1: T-To-T(High) quaternary transitions in human hemoglobin: betaY35A oxy (2MM IHP, 20% PEG) (1 test set)
    1ye1: T-To-T(High) quaternary transitions in human hemoglobin: betaY35A oxy (2MM IHP, 20% PEG) (1 test set)
  • 1xye: T-to-THigh Transitions in Human Hemoglobin: alpha Y42A deoxy low salt
    1xye: T-to-THigh Transitions in Human Hemoglobin: alpha Y42A deoxy low salt
  • 1y4g: T-To-T(High) quaternary transitions in human hemoglobin: betaW37G deoxy low-salt (10 test sets)
    1y4g: T-To-T(High) quaternary transitions in human hemoglobin: betaW37G deoxy low-salt (10 test sets)
  • 1y7d: T-To-T(High) quaternary transitions in human hemoglobin: betaP100G deoxy low-salt (1 test set)
    1y7d: T-To-T(High) quaternary transitions in human hemoglobin: betaP100G deoxy low-salt (1 test set)
  • 1buw: CRYSTAL STRUCTURE OF S-NITROSO-NITROSYL HUMAN HEMOGLOBIN A
    1buw: CRYSTAL STRUCTURE OF S-NITROSO-NITROSYL HUMAN HEMOGLOBIN A
  • 1yh9: T-to-T(High) quaternary transitions in human hemoglobin: HbA OXY (2MM IHP, 20% PEG) (10 test sets)
    1yh9: T-to-T(High) quaternary transitions in human hemoglobin: HbA OXY (2MM IHP, 20% PEG) (10 test sets)
  • 1shr: Crystal structure of ferrocyanide bound human hemoglobin A2 at 1.88A resolution
    1shr: Crystal structure of ferrocyanide bound human hemoglobin A2 at 1.88A resolution
  • 1yeq: T-To-T(High) quaternary transitions in human hemoglobin: betaW37Y OXY (10 test sets)
    1yeq: T-To-T(High) quaternary transitions in human hemoglobin: betaW37Y OXY (10 test sets)
  • 1hco: THE STRUCTURE OF HUMAN CARBONMONOXY HAEMOGLOBIN AT 2.7 ANGSTROMS RESOLUTION
    1hco: THE STRUCTURE OF HUMAN CARBONMONOXY HAEMOGLOBIN AT 2.7 ANGSTROMS RESOLUTION
  • 1coh: STRUCTURE OF HAEMOGLOBIN IN THE DEOXY QUATERNARY STATE WITH LIGAND BOUND AT THE ALPHA HAEMS
    1coh: STRUCTURE OF HAEMOGLOBIN IN THE DEOXY QUATERNARY STATE WITH LIGAND BOUND AT THE ALPHA HAEMS
  • 1ljw: Crystal Structure of Human Carbonmonoxy Hemoglobin at 2.16 A: A Snapshot of the Allosteric Transition
    1ljw: Crystal Structure of Human Carbonmonoxy Hemoglobin at 2.16 A: A Snapshot of the Allosteric Transition
  • 1ye0: T-To-T(High) quaternary transitions in human hemoglobin: betaV33A oxy (2MM IHP, 20% PEG) (1 test set)
    1ye0: T-To-T(High) quaternary transitions in human hemoglobin: betaV33A oxy (2MM IHP, 20% PEG) (1 test set)
  • 1j7y: Crystal structure of partially ligated mutant of HbA
    1j7y: Crystal structure of partially ligated mutant of HbA
  • 1hgc: HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN
    1hgc: HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN
  • 1hbs: REFINED CRYSTAL STRUCTURE OF DEOXYHEMOGLOBIN S. I. RESTRAINED LEAST-SQUARES REFINEMENT AT 3.0-ANGSTROMS RESOLUTION
    1hbs: REFINED CRYSTAL STRUCTURE OF DEOXYHEMOGLOBIN S. I. RESTRAINED LEAST-SQUARES REFINEMENT AT 3.0-ANGSTROMS RESOLUTION
  • 2dn3: 1.25A resolution crystal structure of human hemoglobin in the carbonmonoxy form
    2dn3: 1.25A resolution crystal structure of human hemoglobin in the carbonmonoxy form
  • 1qsi: MAGNESIUM(II)-AND ZINC(II)-PROTOPORPHYRIN IX'S STABILIZE THE LOWEST OXYGEN AFFINITY STATE OF HUMAN HEMOGLOBIN EVEN MORE STRONGLY THAN DEOXYHEME
    1qsi: MAGNESIUM(II)-AND ZINC(II)-PROTOPORPHYRIN IX'S STABILIZE THE LOWEST OXYGEN AFFINITY STATE OF HUMAN HEMOGLOBIN EVEN MORE STRONGLY THAN DEOXYHEME
  • 1qsh: MAGNESIUM(II)-AND ZINC(II)-PROTOPORPHYRIN IX'S STABILIZE THE LOWEST OXYGEN AFFINITY STATE OF HUMAN HEMOGLOBIN EVEN MORE STRONGLY THAN DEOXYHEME
    1qsh: MAGNESIUM(II)-AND ZINC(II)-PROTOPORPHYRIN IX'S STABILIZE THE LOWEST OXYGEN AFFINITY STATE OF HUMAN HEMOGLOBIN EVEN MORE STRONGLY THAN DEOXYHEME
  • 3hhb: THE CRYSTAL STRUCTURE OF HUMAN DEOXYHAEMOGLOBIN AT 1.74 ANGSTROMS RESOLUTION
    3hhb: THE CRYSTAL STRUCTURE OF HUMAN DEOXYHAEMOGLOBIN AT 1.74 ANGSTROMS RESOLUTION
  • 1k0y: X-ray Crystallographic Analyses of Symmetrical Allosteric Effectors of Hemoglobin. Compounds Designed to Link Primary and Secondary Binding Sites
    1k0y: X-ray Crystallographic Analyses of Symmetrical Allosteric Effectors of Hemoglobin. Compounds Designed to Link Primary and Secondary Binding Sites
  • 1gbv: (ALPHA-OXY, BETA-(C112G)DEOXY) T-STATE HUMAN HEMOGLOBIN
    1gbv: (ALPHA-OXY, BETA-(C112G)DEOXY) T-STATE HUMAN HEMOGLOBIN
  • 1ygf: T-to-T(high) quaternary transitions in human hemoglobin: betaH97A oxy (2MM IHP, 20% PEG) (1 test set)
    1ygf: T-to-T(high) quaternary transitions in human hemoglobin: betaH97A oxy (2MM IHP, 20% PEG) (1 test set)
  • 1dxt: HIGH-RESOLUTION X-RAY STUDY OF DEOXY RECOMBINANT HUMAN HEMOGLOBINS SYNTHESIZED FROM BETA-GLOBINS HAVING MUTATED AMINO TERMINI
    1dxt: HIGH-RESOLUTION X-RAY STUDY OF DEOXY RECOMBINANT HUMAN HEMOGLOBINS SYNTHESIZED FROM BETA-GLOBINS HAVING MUTATED AMINO TERMINI
  • 2hbs: THE HIGH RESOLUTION CRYSTAL STRUCTURE OF DEOXYHEMOGLOBIN S
    2hbs: THE HIGH RESOLUTION CRYSTAL STRUCTURE OF DEOXYHEMOGLOBIN S
  • 1y22: T-To-T(High) quaternary transitions in human hemoglobin: betaV33A deoxy low-salt (1 test set)
    1y22: T-To-T(High) quaternary transitions in human hemoglobin: betaV33A deoxy low-salt (1 test set)
  • 1lfv: OXY HEMOGLOBIN (88% RELATIVE HUMIDITY)
    1lfv: OXY HEMOGLOBIN (88% RELATIVE HUMIDITY)
  • 1hac: CROSSLINKED HAEMOGLOBIN
    1hac: CROSSLINKED HAEMOGLOBIN
  • 1y0t: T-to-T(High) Quaternary Transitions in Human Hemoglobin: betaV1M deoxy low-salt (1 test set)
    1y0t: T-to-T(High) Quaternary Transitions in Human Hemoglobin: betaV1M deoxy low-salt (1 test set)
  • 1y8w: T-To-T(High) quaternary transitions in human hemoglobin: alphaR92A oxy (2mM IHP, 20% PEG) (10 test sets)
    1y8w: T-To-T(High) quaternary transitions in human hemoglobin: alphaR92A oxy (2mM IHP, 20% PEG) (10 test sets)
  • 1nih: Structure of deoxy-quaternary haemoglobin with liganded beta subunits
    1nih: Structure of deoxy-quaternary haemoglobin with liganded beta subunits
  • 1rqa: Crystallographic Analysis of the Interaction of Nitric Oxide with Quaternary-T Human Hemoglobin. Beta W73E hemoglobin exposed to NO under anaerobic conditions
    1rqa: Crystallographic Analysis of the Interaction of Nitric Oxide with Quaternary-T Human Hemoglobin. Beta W73E hemoglobin exposed to NO under anaerobic conditions
  • 1lfq: OXY HEMOGLOBIN (93% RELATIVE HUMIDITY)
    1lfq: OXY HEMOGLOBIN (93% RELATIVE HUMIDITY)
  • 1xz2: wild-type hemoglobin deoxy no-salt
    1xz2: wild-type hemoglobin deoxy no-salt
  • 1m9p: Crystalline Human Carbonmonoxy Hemoglobin C Exhibits The R2 Quaternary State at Neutral pH In The Presence of Polyethylene Glycol: The 2.1 Angstrom Resolution Crystal Structure
    1m9p: Crystalline Human Carbonmonoxy Hemoglobin C Exhibits The R2 Quaternary State at Neutral pH In The Presence of Polyethylene Glycol: The 2.1 Angstrom Resolution Crystal Structure
  • 1thb: REFINEMENT OF A PARTIALLY OXYGENATED T STATE HAEMOGLOBIN AT 1.5 ANGSTROMS RESOLUTION
    1thb: REFINEMENT OF A PARTIALLY OXYGENATED T STATE HAEMOGLOBIN AT 1.5 ANGSTROMS RESOLUTION
  • 1yvq: The low salt (PEG) crystal structure of CO Hemoglobin E (betaE26K) approaching physiological pH (pH 7.5)
    1yvq: The low salt (PEG) crystal structure of CO Hemoglobin E (betaE26K) approaching physiological pH (pH 7.5)
  • 2hhb: THE CRYSTAL STRUCTURE OF HUMAN DEOXYHAEMOGLOBIN AT 1.74 ANGSTROMS RESOLUTION
    2hhb: THE CRYSTAL STRUCTURE OF HUMAN DEOXYHAEMOGLOBIN AT 1.74 ANGSTROMS RESOLUTION
  • 1xy0: T-to-THigh Transitions in Human Hemoglobin: alphaK40G deoxy low-salt
    1xy0: T-to-THigh Transitions in Human Hemoglobin: alphaK40G deoxy low-salt
  • 6hbw: Crystal structure of deoxy-human hemoglobin beta6 glu->trp
    6hbw: Crystal structure of deoxy-human hemoglobin beta6 glu->trp
  • 1bab: HEMOGLOBIN THIONVILLE: AN ALPHA-CHAIN VARIANT WITH A SUBSTITUTION OF A GLUTAMATE FOR VALINE AT NA-1 AND HAVING AN ACETYLATED METHIONINE NH2 TERMINUS
    1bab: HEMOGLOBIN THIONVILLE: AN ALPHA-CHAIN VARIANT WITH A SUBSTITUTION OF A GLUTAMATE FOR VALINE AT NA-1 AND HAVING AN ACETYLATED METHIONINE NH2 TERMINUS
  • 2hhd: OXYGEN AFFINITY MODULATION BY THE N-TERMINI OF THE BETA-CHAINS IN HUMAN AND BOVINE HEMOGLOBIN
    2hhd: OXYGEN AFFINITY MODULATION BY THE N-TERMINI OF THE BETA-CHAINS IN HUMAN AND BOVINE HEMOGLOBIN
  • 2dn1: 1.25A resolution crystal structure of human hemoglobin in the oxy form
    2dn1: 1.25A resolution crystal structure of human hemoglobin in the oxy form
  • 1y09: T-to-T(High) Quaternary Transitions in Human Hemoglobin: alphaN97A deoxy low-salt
    1y09: T-to-T(High) Quaternary Transitions in Human Hemoglobin: alphaN97A deoxy low-salt
  • 1lfl: DEOXY HEMOGLOBIN (90% RELATIVE HUMIDITY)
    1lfl: DEOXY HEMOGLOBIN (90% RELATIVE HUMIDITY)
  • 1y0c: T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaY140F deoxy low-salt
    1y0c: T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaY140F deoxy low-salt
  • 1sdl: CROSS-LINKED, CARBONMONOXY HEMOGLOBIN A
    1sdl: CROSS-LINKED, CARBONMONOXY HEMOGLOBIN A
  • 1o1o: Deoxy hemoglobin (A,C:V1M,V62L; B,D:V1M,V67L)
    1o1o: Deoxy hemoglobin (A,C:V1M,V62L; B,D:V1M,V67L)
  • 1yih: T-to-T(High) quaternary transitions in human hemoglobin: betaP100A oxy (2.2MM IHP, 20% PEG) (1 test set)
    1yih: T-to-T(High) quaternary transitions in human hemoglobin: betaP100A oxy (2.2MM IHP, 20% PEG) (1 test set)
  • 1qxd: Structural Basis for the Potent Antisickling Effect of a Novel Class of 5-Membered Heterocyclic Aldehydic Compounds
    1qxd: Structural Basis for the Potent Antisickling Effect of a Novel Class of 5-Membered Heterocyclic Aldehydic Compounds
  • 1y4q: T-To-T(High) quaternary transitions in human hemoglobin: betaF42A deoxy low-salt (1 test set)
    1y4q: T-To-T(High) quaternary transitions in human hemoglobin: betaF42A deoxy low-salt (1 test set)
  • 1y85: T-To-T(High) quaternary transitions in human hemoglobin: desHIS146beta deoxy low-salt
    1y85: T-To-T(High) quaternary transitions in human hemoglobin: desHIS146beta deoxy low-salt
  • 1fn3: CRYSTAL STRUCTURE OF NICKEL RECONSTITUTED HEMOGLOBIN-A CASE FOR PERMANENT, T-STATE HEMOGLOBIN
    1fn3: CRYSTAL STRUCTURE OF NICKEL RECONSTITUTED HEMOGLOBIN-A CASE FOR PERMANENT, T-STATE HEMOGLOBIN
  • 1a9w: HUMAN EMBRYONIC GOWER II CARBONMONOXY HEMOGLOBIN
    1a9w: HUMAN EMBRYONIC GOWER II CARBONMONOXY HEMOGLOBIN
  • 1jy7: THE STRUCTURE OF HUMAN METHEMOGLOBIN. THE VARIATION OF A THEME
    1jy7: THE STRUCTURE OF HUMAN METHEMOGLOBIN. THE VARIATION OF A THEME
  • 1a3n: DEOXY HUMAN HEMOGLOBIN
    1a3n: DEOXY HUMAN HEMOGLOBIN
  • 1yg5: T-To-T(High) quaternary transitions in human hemoglobin: betaW37H OXY (2MM IHP, 20% PEG) (10 test sets)
    1yg5: T-To-T(High) quaternary transitions in human hemoglobin: betaW37H OXY (2MM IHP, 20% PEG) (10 test sets)
  • 1dxv: HIGH-RESOLUTION X-RAY STUDY OF DEOXY RECOMBINANT HUMAN HEMOGLOBINS SYNTHESIZED FROM BETA-GLOBINS HAVING MUTATED AMINO TERMINI
    1dxv: HIGH-RESOLUTION X-RAY STUDY OF DEOXY RECOMBINANT HUMAN HEMOGLOBINS SYNTHESIZED FROM BETA-GLOBINS HAVING MUTATED AMINO TERMINI
  • 1hga: HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN
    1hga: HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN
  • 1b86: HUMAN DEOXYHAEMOGLOBIN-2,3-DIPHOSPHOGLYCERATE COMPLEX
    1b86: HUMAN DEOXYHAEMOGLOBIN-2,3-DIPHOSPHOGLYCERATE COMPLEX
  • 1xz5: T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaL91A deoxy low-salt
    1xz5: T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaL91A deoxy low-salt
  • 1y46: T-To-T(High) quaternary transitions in human hemoglobin: betaW37Y deoxy low-salt (10 test sets)
    1y46: T-To-T(High) quaternary transitions in human hemoglobin: betaW37Y deoxy low-salt (10 test sets)
  • 1yen: T-To-T(High) quaternary transitions in human hemoglobin: betaP36A oxy (2MM IHP, 20% PEG) (10 test sets)
    1yen: T-To-T(High) quaternary transitions in human hemoglobin: betaP36A oxy (2MM IHP, 20% PEG) (10 test sets)
  • 1yzi: A novel quaternary structure of human carbonmonoxy hemoglobin
    1yzi: A novel quaternary structure of human carbonmonoxy hemoglobin
  • 2hhe: OXYGEN AFFINITY MODULATION BY THE N-TERMINI OF THE BETA CHAINS IN HUMAN AND BOVINE HEMOGLOBIN
    2hhe: OXYGEN AFFINITY MODULATION BY THE N-TERMINI OF THE BETA CHAINS IN HUMAN AND BOVINE HEMOGLOBIN
  • 1a01: HEMOGLOBIN (VAL BETA1 MET, TRP BETA37 ALA) MUTANT
    1a01: HEMOGLOBIN (VAL BETA1 MET, TRP BETA37 ALA) MUTANT
  • 2hbf: HIGH RESOLUTION X-RAY STRUCTURES OF MYOGLOBIN-AND HEMOGLOBIN-ALKYL ISOCYANIDE COMPLEXES
    2hbf: HIGH RESOLUTION X-RAY STRUCTURES OF MYOGLOBIN-AND HEMOGLOBIN-ALKYL ISOCYANIDE COMPLEXES
  • 2d5z: Crystal structure of T-state human hemoglobin complexed with three L35 molecules
    2d5z: Crystal structure of T-state human hemoglobin complexed with three L35 molecules
  • 1c7d: DEOXY RHB1.2 (RECOMBINANT HEMOGLOBIN)
    1c7d: DEOXY RHB1.2 (RECOMBINANT HEMOGLOBIN)
  • 3d17: A triply ligated crystal structure of relaxed state human hemoglobin
    3d17: A triply ligated crystal structure of relaxed state human hemoglobin
  • 2hbc: HIGH RESOLUTION X-RAY STRUCTURES OF MYOGLOBIN-AND HEMOGLOBIN-ALKYL ISOCYANIDE COMPLEXES
    2hbc: HIGH RESOLUTION X-RAY STRUCTURES OF MYOGLOBIN-AND HEMOGLOBIN-ALKYL ISOCYANIDE COMPLEXES
  • 1o1i: Cyanomet hemoglobin (A-GLY-C:V1M,L29F,H58Q; B,D:V1M,L106W)
    1o1i: Cyanomet hemoglobin (A-GLY-C:V1M,L29F,H58Q; B,D:V1M,L106W)
  • 1gli: DEOXYHEMOGLOBIN T38W (ALPHA CHAINS), V1G (ALPHA AND BETA CHAINS)
    1gli: DEOXYHEMOGLOBIN T38W (ALPHA CHAINS), V1G (ALPHA AND BETA CHAINS)
  • 1qi8: DEOXYGENATED STRUCTURE OF A DISTAL POCKET HEMOGLOBIN MUTANT
    1qi8: DEOXYGENATED STRUCTURE OF A DISTAL POCKET HEMOGLOBIN MUTANT
  • 1a0z: HEMOGLOBIN (VAL BETA1 MET) MUTANT
    1a0z: HEMOGLOBIN (VAL BETA1 MET) MUTANT
  • 1cmy: THE MUTATION BETA99 ASP-TYR STABILIZES Y-A NEW, COMPOSITE QUATERNARY STATE OF HUMAN HEMOGLOBIN
    1cmy: THE MUTATION BETA99 ASP-TYR STABILIZES Y-A NEW, COMPOSITE QUATERNARY STATE OF HUMAN HEMOGLOBIN
  • 1o1p: Deoxy hemoglobin (A-GLY-C:V1M; B,D:V1M,C93A,N108K)
    1o1p: Deoxy hemoglobin (A-GLY-C:V1M; B,D:V1M,C93A,N108K)
  • 1j7w: Crystal structure of deoxy HbbetaYQ, a site directed mutant of HbA
    1j7w: Crystal structure of deoxy HbbetaYQ, a site directed mutant of HbA
  • 1aj9: R-STATE HUMAN CARBONMONOXYHEMOGLOBIN ALPHA-A53S
    1aj9: R-STATE HUMAN CARBONMONOXYHEMOGLOBIN ALPHA-A53S
  • 1dke: NI BETA HEME HUMAN HEMOGLOBIN
    1dke: NI BETA HEME HUMAN HEMOGLOBIN
  • 1bz1: HEMOGLOBIN (ALPHA + MET) VARIANT
    1bz1: HEMOGLOBIN (ALPHA + MET) VARIANT
  • 1o1m: Deoxy hemoglobin (A-GLYGLYGLY-C:V1M,L29F,H58Q B,D:V1M,V67W)
    1o1m: Deoxy hemoglobin (A-GLYGLYGLY-C:V1M,L29F,H58Q B,D:V1M,V67W)
  • 1y4f: T-To-T(High) quaternary transitions in human hemoglobin: betaW37A deoxy low-salt (10 test sets)
    1y4f: T-To-T(High) quaternary transitions in human hemoglobin: betaW37A deoxy low-salt (10 test sets)
  • 1y2z: T-To-T(High) quaternary transitions in human hemoglobin: betaV34G deoxy low-salt (1 test set)
    1y2z: T-To-T(High) quaternary transitions in human hemoglobin: betaV34G deoxy low-salt (1 test set)
  • 1rq3: Crystallographic Analysis of the Interaction of Nitric Oxide with Quaternary-T Human Deoxyhemoglobin, Deoxyhemoglobin
    1rq3: Crystallographic Analysis of the Interaction of Nitric Oxide with Quaternary-T Human Deoxyhemoglobin, Deoxyhemoglobin
  • 1j3z: Direct observation of photolysis-induced tertiary structural changes in human haemoglobin; Crystal structure of alpha(Fe-CO)-beta(Ni) hemoglobin (laser unphotolysed)
    1j3z: Direct observation of photolysis-induced tertiary structural changes in human haemoglobin; Crystal structure of alpha(Fe-CO)-beta(Ni) hemoglobin (laser unphotolysed)
  • 1lft: OXY HEMOGLOBIN (90% RELATIVE HUMIDITY)
    1lft: OXY HEMOGLOBIN (90% RELATIVE HUMIDITY)
  • 1lfz: OXY HEMOGLOBIN (25% METHANOL)
    1lfz: OXY HEMOGLOBIN (25% METHANOL)
  • 1bij: CROSSLINKED, DEOXY HUMAN HEMOGLOBIN A
    1bij: CROSSLINKED, DEOXY HUMAN HEMOGLOBIN A
  • 1cls: CROSS-LINKED HUMAN HEMOGLOBIN DEOXY
    1cls: CROSS-LINKED HUMAN HEMOGLOBIN DEOXY
  • 2dn2: 1.25A resolution crystal structure of human hemoglobin in the deoxy form
    2dn2: 1.25A resolution crystal structure of human hemoglobin in the deoxy form
  • 1vwt: T STATE HUMAN HEMOGLOBIN [ALPHA V96W], ALPHA AQUOMET, BETA DEOXY
    1vwt: T STATE HUMAN HEMOGLOBIN [ALPHA V96W], ALPHA AQUOMET, BETA DEOXY
  • 1y7z: T-To-T(High) quaternary transitions in human hemoglobin: betaN108A deoxy low-salt (1 test set)
    1y7z: T-To-T(High) quaternary transitions in human hemoglobin: betaN108A deoxy low-salt (1 test set)
  • 1nej: Crystalline Human Carbonmonoxy Hemoglobin S (Liganded Sickle Cell Hemoglobin) Exhibits The R2 Quaternary State At Neutral pH In The Presence Of Polyethylene Glycol: The 2.1 Angstrom Resolution Crystal Structure
    1nej: Crystalline Human Carbonmonoxy Hemoglobin S (Liganded Sickle Cell Hemoglobin) Exhibits The R2 Quaternary State At Neutral pH In The Presence Of Polyethylene Glycol: The 2.1 Angstrom Resolution Crystal Structure
  • 1yev: T-To-T(High) quaternary transitions in human hemoglobin: betaW37E OXY (10 test sets)
    1yev: T-To-T(High) quaternary transitions in human hemoglobin: betaW37E OXY (10 test sets)
  • 1yhe: T-To-T(High) quaternary transitions in human hemoglobin: HbA OXY (5.0MM IHP, 20% PEG) (10 test sets)
    1yhe: T-To-T(High) quaternary transitions in human hemoglobin: HbA OXY (5.0MM IHP, 20% PEG) (10 test sets)
  • 1o1k: Deoxy hemoglobin (A,C:V1M; B,D:V1M,V67W)
    1o1k: Deoxy hemoglobin (A,C:V1M; B,D:V1M,V67W)
  • 1fdh: STRUCTURE OF HUMAN FOETAL DEOXYHAEMOGLOBIN
    1fdh: STRUCTURE OF HUMAN FOETAL DEOXYHAEMOGLOBIN
  • 1a0u: HEMOGLOBIN (VAL BETA1 MET) MUTANT
    1a0u: HEMOGLOBIN (VAL BETA1 MET) MUTANT
  • 1hab: CROSSLINKED HAEMOGLOBIN
    1hab: CROSSLINKED HAEMOGLOBIN
  • 1y0a: T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaY140A deoxy low-salt
    1y0a: T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaY140A deoxy low-salt
  • 1rps: Crystallographic Analysis of the Interaction of Nitric Oxide with Quaternary-T Human Hemoglobin. Hemoglobin exposed to NO under anerobic conditions
    1rps: Crystallographic Analysis of the Interaction of Nitric Oxide with Quaternary-T Human Hemoglobin. Hemoglobin exposed to NO under anerobic conditions
  • 1o1n: Deoxy hemoglobin (A-GLYGLYGLY-C:V1M,L29W; B,D:V1M)
    1o1n: Deoxy hemoglobin (A-GLYGLYGLY-C:V1M,L29W; B,D:V1M)
  • 1yie: T-to-thigh quaternary transitions in human hemoglobin: betaW37A oxy (2.2MM IHP, 13% PEG) (1 test set)
    1yie: T-to-thigh quaternary transitions in human hemoglobin: betaW37A oxy (2.2MM IHP, 13% PEG) (1 test set)
  • 2hbe: HIGH RESOLUTION X-RAY STRUCTURES OF MYOGLOBIN-AND HEMOGLOBIN-ALKYL ISOCYANIDE COMPLEXES
    2hbe: HIGH RESOLUTION X-RAY STRUCTURES OF MYOGLOBIN-AND HEMOGLOBIN-ALKYL ISOCYANIDE COMPLEXES
  • 1y5k: T-To-T(High) quaternary transitions in human hemoglobin: betaD99A deoxy low-salt (10 test sets)
    1y5k: T-To-T(High) quaternary transitions in human hemoglobin: betaD99A deoxy low-salt (10 test sets)
  • 1hba: HIGH-RESOLUTION X-RAY STUDY OF DEOXYHEMOGLOBIN ROTHSCHILD 37BETA TRP-> ARG: A MUTATION THAT CREATES AN INTERSUBUNIT CHLORIDE-BINDING SITE
    1hba: HIGH-RESOLUTION X-RAY STUDY OF DEOXYHEMOGLOBIN ROTHSCHILD 37BETA TRP-> ARG: A MUTATION THAT CREATES AN INTERSUBUNIT CHLORIDE-BINDING SITE
  • 1nqp: Crystal structure of Human hemoglobin E at 1.73 A resolution
    1nqp: Crystal structure of Human hemoglobin E at 1.73 A resolution
  • 1a00: HEMOGLOBIN (VAL BETA1 MET, TRP BETA37 TYR) MUTANT
    1a00: HEMOGLOBIN (VAL BETA1 MET, TRP BETA37 TYR) MUTANT
  • 2dxm: Neutron Structure Analysis of Deoxy Human Hemoglobin
    2dxm: Neutron Structure Analysis of Deoxy Human Hemoglobin
  • 1y7c: T-To-T(High) quaternary transitions in human hemoglobin: betaP100A deoxy low-salt (1 test set)
    1y7c: T-To-T(High) quaternary transitions in human hemoglobin: betaP100A deoxy low-salt (1 test set)
  • 1o1j: Deoxy hemoglobin (A-GLY-C:V1M,L29F,H58Q; B,D:V1M,L106W)
    1o1j: Deoxy hemoglobin (A-GLY-C:V1M,L29F,H58Q; B,D:V1M,L106W)
  • 1uiw: Crystal Structures of Unliganded and Half-Liganded Human Hemoglobin Derivatives Cross-Linked between Lys 82beta1 and Lys 82beta2
    1uiw: Crystal Structures of Unliganded and Half-Liganded Human Hemoglobin Derivatives Cross-Linked between Lys 82beta1 and Lys 82beta2
  • 2hco: THE STRUCTURE OF HUMAN CARBONMONOXY HAEMOGLOBIN AT 2.7 ANGSTROMS RESOLUTION
    2hco: THE STRUCTURE OF HUMAN CARBONMONOXY HAEMOGLOBIN AT 2.7 ANGSTROMS RESOLUTION
  • 1y5f: T-To-T(High) quaternary transitions in human hemoglobin: betaL96A deoxy low-salt (1 test set)
    1y5f: T-To-T(High) quaternary transitions in human hemoglobin: betaL96A deoxy low-salt (1 test set)
  • 1hgb: HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN
    1hgb: HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN
  • 1xxt: The T-to-T High Transitions in Human Hemoglobin: wild-type deoxy Hb A (low salt, one test set)
    1xxt: The T-to-T High Transitions in Human Hemoglobin: wild-type deoxy Hb A (low salt, one test set)
  • 2h35: Solution structure of Human normal adult hemoglobin
    2h35: Solution structure of Human normal adult hemoglobin
  • 1r1x: Crystal structure of oxy-human hemoglobin Bassett at 2.15 angstrom
    1r1x: Crystal structure of oxy-human hemoglobin Bassett at 2.15 angstrom
  • 1y83: T-To-T(High) quaternary transitions in human hemoglobin: betaY145G deoxy low-salt (1 test set)
    1y83: T-To-T(High) quaternary transitions in human hemoglobin: betaY145G deoxy low-salt (1 test set)
  • 1xzv: T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaP95A deoxy low-salt
    1xzv: T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaP95A deoxy low-salt
  • 1qxe: Structural Basis for the Potent Antisickling Effect of a Novel Class of 5-Membered Heterocyclic Aldehydic Compounds
    1qxe: Structural Basis for the Potent Antisickling Effect of a Novel Class of 5-Membered Heterocyclic Aldehydic Compounds
  • 1lfy: OXY HEMOGLOBIN (84% RELATIVE HUMIDITY)
    1lfy: OXY HEMOGLOBIN (84% RELATIVE HUMIDITY)
  • 1mko: A Fourth Quaternary Structure of Human Hemoglobin A at 2.18 A Resolution
    1mko: A Fourth Quaternary Structure of Human Hemoglobin A at 2.18 A Resolution
  • 1dxu: HIGH-RESOLUTION X-RAY STUDY OF DEOXY RECOMBINANT HUMAN HEMOGLOBINS SYNTHESIZED FROM BETA-GLOBINS HAVING MUTATED AMINO TERMINI
    1dxu: HIGH-RESOLUTION X-RAY STUDY OF DEOXY RECOMBINANT HUMAN HEMOGLOBINS SYNTHESIZED FROM BETA-GLOBINS HAVING MUTATED AMINO TERMINI
  • 1g9v: HIGH RESOLUTION CRYSTAL STRUCTURE OF DEOXY HEMOGLOBIN COMPLEXED WITH A POTENT ALLOSTERIC EFFECTOR
    1g9v: HIGH RESOLUTION CRYSTAL STRUCTURE OF DEOXY HEMOGLOBIN COMPLEXED WITH A POTENT ALLOSTERIC EFFECTOR
  • 1sdk: CROSS-LINKED, CARBONMONOXY HEMOGLOBIN A
    1sdk: CROSS-LINKED, CARBONMONOXY HEMOGLOBIN A
  • 1yff: STRUCTURE OF HUMAN CARBONMONOXYHEMOGLOBIN C (BETA E6K): TWO QUATERNARY STATES (R2 and R3) IN ONE CRYSTAL
    1yff: STRUCTURE OF HUMAN CARBONMONOXYHEMOGLOBIN C (BETA E6K): TWO QUATERNARY STATES (R2 and R3) IN ONE CRYSTAL
  • 1ye2: T-To-T(High) quaternary transitions in human hemoglobin: betaY35F oxy (2MM IHP, 20% PEG) (1 test set)
    1ye2: T-To-T(High) quaternary transitions in human hemoglobin: betaY35F oxy (2MM IHP, 20% PEG) (1 test set)
  • 1y4p: T-To-T(high) quaternary transitions in human hemoglobin: betaW37E deoxy low-salt (10 test sets)
    1y4p: T-To-T(high) quaternary transitions in human hemoglobin: betaW37E deoxy low-salt (10 test sets)
  • 1y4b: T-To-T(High) quaternary transitions in human hemoglobin: betaW37H deoxy low-salt (10 test sets)
    1y4b: T-To-T(High) quaternary transitions in human hemoglobin: betaW37H deoxy low-salt (10 test sets)
  • 1y0w: T-to-THigh quaternary Transitions in Human Hemoglobin: betaV1M deoxy low-salt (10 test sets)
    1y0w: T-to-THigh quaternary Transitions in Human Hemoglobin: betaV1M deoxy low-salt (10 test sets)
  • 1j41: Direct observation of photolysis-induced tertiary structural changes in human haemoglobin; Crystal structure of alpha(Ni)-beta(Fe) hemoglobin (laser photolysed)
    1j41: Direct observation of photolysis-induced tertiary structural changes in human haemoglobin; Crystal structure of alpha(Ni)-beta(Fe) hemoglobin (laser photolysed)
  • 1kd2: Crystal Structure of Human Deoxyhemoglobin in Absence of Any Anions
    1kd2: Crystal Structure of Human Deoxyhemoglobin in Absence of Any Anions
  • 1y35: T-To-T(High) quaternary transitions in human hemoglobin: betaY35F deoxy low-salt (1 test set)
    1y35: T-To-T(High) quaternary transitions in human hemoglobin: betaY35F deoxy low-salt (1 test set)
  • 1si4: Crystal structure of Human hemoglobin A2 (in R2 state) at 2.2 A resolution
    1si4: Crystal structure of Human hemoglobin A2 (in R2 state) at 2.2 A resolution
  • 1ygd: T-To-T(High) quaternary transitions in human hemoglobin: betaW37E alpha zinc beta oxy (10 TEST SETS)
    1ygd: T-To-T(High) quaternary transitions in human hemoglobin: betaW37E alpha zinc beta oxy (10 TEST SETS)
  • 1c7b: DEOXY RHB1.0 (RECOMBINANT HEMOGLOBIN)
    1c7b: DEOXY RHB1.0 (RECOMBINANT HEMOGLOBIN)
  • 1yhr: T-To-T(High) quaternary transitions in human hemoglobin: HbA OXY (10.0MM IHP, 20% PEG) (10 test sets)
    1yhr: T-To-T(High) quaternary transitions in human hemoglobin: HbA OXY (10.0MM IHP, 20% PEG) (10 test sets)
  • 1rq4: Crystallographic Analysis of the Interaction of Nitric Oxide with Quaternary-T Human Hemoglobin, HEMOGLOBIN EXPOSED TO NO UNDER AEROBIC CONDITIONS
    1rq4: Crystallographic Analysis of the Interaction of Nitric Oxide with Quaternary-T Human Hemoglobin, HEMOGLOBIN EXPOSED TO NO UNDER AEROBIC CONDITIONS
  • 1y5j: T-To-T(High) quaternary transitions in human hemoglobin: betaH97A deoxy low-salt (1 test set)
    1y5j: T-To-T(High) quaternary transitions in human hemoglobin: betaH97A deoxy low-salt (1 test set)
  • 1y4v: T-To-T(High) quaternary transitions in human hemoglobin: betaC93A deoxy low-salt (1 test set)
    1y4v: T-To-T(High) quaternary transitions in human hemoglobin: betaC93A deoxy low-salt (1 test set)
  • 1xz7: T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaR92A deoxy low-salt
    1xz7: T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaR92A deoxy low-salt
  • 1y31: T-To-T(High) quaternary transitions in human hemoglobin: betaY35A deoxy low-salt (1 test set)
    1y31: T-To-T(High) quaternary transitions in human hemoglobin: betaY35A deoxy low-salt (1 test set)
  • 1bz0: HEMOGLOBIN A (HUMAN, DEOXY, HIGH SALT)
    1bz0: HEMOGLOBIN A (HUMAN, DEOXY, HIGH SALT)
  • 1y7g: T-To-T(high) quaternary transitions in human hemoglobin: betaN102A deoxy low-salt (1 test set)
    1y7g: T-To-T(high) quaternary transitions in human hemoglobin: betaN102A deoxy low-salt (1 test set)
  • 1hho: STRUCTURE OF HUMAN OXYHAEMOGLOBIN AT 2.1 ANGSTROMS RESOLUTION
    1hho: STRUCTURE OF HUMAN OXYHAEMOGLOBIN AT 2.1 ANGSTROMS RESOLUTION
  • 1r1y: Crystal structure of deoxy-human hemoglobin Bassett at 1.8 angstrom
    1r1y: Crystal structure of deoxy-human hemoglobin Bassett at 1.8 angstrom
  • 1y0d: T-to-THigh Quaternary Transitions in Human Hemoglobin: desArg141alpha deoxy low-salt
    1y0d: T-to-THigh Quaternary Transitions in Human Hemoglobin: desArg141alpha deoxy low-salt
  • 1bbb: A THIRD QUATERNARY STRUCTURE OF HUMAN HEMOGLOBIN A AT 1.7-ANGSTROMS RESOLUTION
    1bbb: A THIRD QUATERNARY STRUCTURE OF HUMAN HEMOGLOBIN A AT 1.7-ANGSTROMS RESOLUTION
  • 1xz4: Intersubunit Interactions Associated with Tyr42alpha Stabilize the Quaternary-T Tetramer but are not Major Quaternary Constraints in Deoxyhemoglobin: alphaY42A deoxyhemoglobin no-salt
    1xz4: Intersubunit Interactions Associated with Tyr42alpha Stabilize the Quaternary-T Tetramer but are not Major Quaternary Constraints in Deoxyhemoglobin: alphaY42A deoxyhemoglobin no-salt
  • 1a3o: ARTIFICIAL MUTANT (ALPHA Y42H) OF DEOXY HEMOGLOBIN
    1a3o: ARTIFICIAL MUTANT (ALPHA Y42H) OF DEOXY HEMOGLOBIN
  • 1rvw: R STATE HUMAN HEMOGLOBIN [ALPHA V96W], CARBONMONOXY
    1rvw: R STATE HUMAN HEMOGLOBIN [ALPHA V96W], CARBONMONOXY
  • 1y01: Crystal structure of AHSP bound to Fe(II) alpha-hemoglobin
    1y01: Crystal structure of AHSP bound to Fe(II) alpha-hemoglobin
  • 1y45: T-To-T(high) quaternary transitions in human hemoglobin: betaP36A deoxy low-salt (10 test sets)
    1y45: T-To-T(high) quaternary transitions in human hemoglobin: betaP36A deoxy low-salt (10 test sets)
  • 4hhb: THE CRYSTAL STRUCTURE OF HUMAN DEOXYHAEMOGLOBIN AT 1.74 ANGSTROMS RESOLUTION
    4hhb: THE CRYSTAL STRUCTURE OF HUMAN DEOXYHAEMOGLOBIN AT 1.74 ANGSTROMS RESOLUTION
  • 1bzz: HEMOGLOBIN (ALPHA V1M) MUTANT
    1bzz: HEMOGLOBIN (ALPHA V1M) MUTANT
  • 2d60: Crystal structure of deoxy human hemoglobin complexed with two L35 molecules
    2d60: Crystal structure of deoxy human hemoglobin complexed with two L35 molecules
  • 1hdb: ANALYSIS OF THE CRYSTAL STRUCTURE, MOLECULAR MODELING AND INFRARED SPECTROSCOPY OF THE DISTAL BETA-HEME POCKET VALINE67(E11)-THREONINE MUTATION OF HEMOGLOBIN
    1hdb: ANALYSIS OF THE CRYSTAL STRUCTURE, MOLECULAR MODELING AND INFRARED SPECTROSCOPY OF THE DISTAL BETA-HEME POCKET VALINE67(E11)-THREONINE MUTATION OF HEMOGLOBIN
  • 1yvt: The high salt (phosphate) crystal structure of CO Hemoglobin E (Glu26Lys) at physiological pH (pH 7.35)
    1yvt: The high salt (phosphate) crystal structure of CO Hemoglobin E (Glu26Lys) at physiological pH (pH 7.35)
  • 2yrs: Human hemoglobin D Los Angeles: crystal structure
    2yrs: Human hemoglobin D Los Angeles: crystal structure
  • 1yeo: T-To-T(High) quaternary transitions in human hemoglobin: betaW37A OXY (10 test sets)
    1yeo: T-To-T(High) quaternary transitions in human hemoglobin: betaW37A OXY (10 test sets)
  • 1j40: Direct observation of photolysis-induced tertiary structural changes in human haemoglobin; Crystal structure of alpha(Ni)-beta(Fe-CO) hemoglobin (laser unphotolysed)
    1j40: Direct observation of photolysis-induced tertiary structural changes in human haemoglobin; Crystal structure of alpha(Ni)-beta(Fe-CO) hemoglobin (laser unphotolysed)
  • 1j7s: Crystal Structure of deoxy HbalphaYQ, a mutant of HbA
    1j7s: Crystal Structure of deoxy HbalphaYQ, a mutant of HbA
  • 1j3y: Direct observation of photolysis-induced tertiary structural changes in human hemoglobin; Crystal structure of alpha(Fe)-beta(Ni) hemoglobin (laser photolysed)
    1j3y: Direct observation of photolysis-induced tertiary structural changes in human hemoglobin; Crystal structure of alpha(Fe)-beta(Ni) hemoglobin (laser photolysed)
  • 1z8u: Crystal structure of oxidized alpha hemoglobin bound to AHSP
    1z8u: Crystal structure of oxidized alpha hemoglobin bound to AHSP
  • 1ydz: T-To-T(High) quaternary transitions in human hemoglobin: alphaY140F oxy (2MM IHP, 20% PEG) (1 test set)
    1ydz: T-To-T(High) quaternary transitions in human hemoglobin: alphaY140F oxy (2MM IHP, 20% PEG) (1 test set)
  • 1k1k: Structure of Mutant Human Carbonmonoxyhemoglobin C (beta E6K) at 2.0 Angstrom Resolution in Phosphate Buffer.
    1k1k: Structure of Mutant Human Carbonmonoxyhemoglobin C (beta E6K) at 2.0 Angstrom Resolution in Phosphate Buffer.
  • 1c7c: DEOXY RHB1.1 (RECOMBINANT HEMOGLOBIN)
    1c7c: DEOXY RHB1.1 (RECOMBINANT HEMOGLOBIN)
  • 2hbd: HIGH RESOLUTION X-RAY STRUCTURES OF MYOGLOBIN-AND HEMOGLOBIN-ALKYL ISOCYANIDE COMPLEXES
    2hbd: HIGH RESOLUTION X-RAY STRUCTURES OF MYOGLOBIN-AND HEMOGLOBIN-ALKYL ISOCYANIDE COMPLEXES
  • 1gbu: DEOXY (BETA-(C93A,C112G)) HUMAN HEMOGLOBIN
    1gbu: DEOXY (BETA-(C93A,C112G)) HUMAN HEMOGLOBIN
  • 1aby: CYANOMET RHB1.1 (RECOMBINANT HEMOGLOBIN)
    1aby: CYANOMET RHB1.1 (RECOMBINANT HEMOGLOBIN)
  • 1gzx: OXY T STATE HAEMOGLOBIN: OXYGEN BOUND AT ALL FOUR HAEMS
    1gzx: OXY T STATE HAEMOGLOBIN: OXYGEN BOUND AT ALL FOUR HAEMS
  • 1xzu: T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaD94G deoxy low-salt
    1xzu: T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaD94G deoxy low-salt
  • 1yeu: T-To-T(High) quaternary transitions in human hemoglobin: betaW37G OXY (10 test sets)
    1yeu: T-To-T(High) quaternary transitions in human hemoglobin: betaW37G OXY (10 test sets)
  • 1o1l: Deoxy hemoglobin (A-GLY-C:V1M,L29W,H58Q; B,D:V1M)
    1o1l: Deoxy hemoglobin (A-GLY-C:V1M,L29W,H58Q; B,D:V1M)
  • 1abw: DEOXY RHB1.1 (RECOMBINANT HEMOGLOBIN)
    1abw: DEOXY RHB1.1 (RECOMBINANT HEMOGLOBIN)
  • 1ird: Crystal Structure of Human Carbonmonoxy-Haemoglobin at 1.25 A Resolution
    1ird: Crystal Structure of Human Carbonmonoxy-Haemoglobin at 1.25 A Resolution
  • 1y4r: T-To-T(High) quaternary transitions in human hemoglobin: betaF45A deoxy low-salt (1 test set)
    1y4r: T-To-T(High) quaternary transitions in human hemoglobin: betaF45A deoxy low-salt (1 test set)
  • v
  • t
  • e
Proteins that contain heme (hemoproteins)
Globins
Hemoglobin
Subunits
Alpha locus on 16:
Beta locus on 11:
Tetramers
stages of
development:
Embryonic
Fetal
Adult
pathology:
Compounds
Other human
Nonhuman
Other
human:
plant:
Other
see also disorders of globin and globulin proteins