HLA-B

已知的結構

人类UniProt搜索: PDBe RCSB

PDBID列表

3VCL、4U1H、4U1K、5EO1、5EO0,%%s1AGB、1AGC、1AGD、1AGE、1AGF、1M05、1MI5、3FFC、3SJV、3SKM、3SKO、3SPV、3X13、3X14、4QRP、4QRQ、4QRS、4QRT、4QRU,%%s4O2C、4O2E、4O2F,%%s3LN4、3LN5,%%s4U1J、4U1M、4U1N,%%s4U1I、4U1L、4U1S,%%s1HSA、1JGD、1JGE、1K5N、1OF2、1OGT、1UXS、1UXW、1W0V、1W0W、2A83、2BSR、2BSS、2BST、3B3I、3B6S、3BP4、3BP7、3CZF、3D18、3DTX、3HCV、3LV3、4G8G、4G8I、4G9D、4G9F、5DEF、5DEG,%%s1A1N、1A9B、1A9E、1CG9、1XH3、1ZHK、1ZHL、1ZSD、2AK4、2AXF、2AXG、2H6P、2NW3、2NX5、3BW9、3BWA、3KWW、3KXF、3LKN、3LKO、3LKP、3LKQ、3LKR、3LKS、3MV7、3MV8、3MV9、3VFS、3VFT、3VFU、3VFV、3VFW、4LNR、4PR5、4PRN、4QRR,%%s1A1M、1A1O,%%s2BVO、2BVP、2BVQ、2HJL、2RFX、2YPK、2YPL、3UPR、3VH8、3VRI、3VRJ、3WUW、3X11、3X12、5B39、5B38,%%s4JQV、4XXC,%%s1XR8、1XR9、3C9N,%%s4LCY,%%s1M6O、1N2R、1SYV、3DX6、3DX7、3DX8、3DXA、3KPL、3KPM、3KPN、3KPO、3KPP、3KPQ、3KPR、3KPS、3L3D、3L3G、3L3I、3L3J、4JQX,%%s1E27、1E28、4MJI,%%s3W39

識別號

别名

HLA-B；, AS, SPDA1, Bw-47, Bw-50, major histocompatibility complex, class I, B, B-4901, B-5001, HEL-S-83, HLA-B*45ZJ, HLA-B-3506, HLA-B-3905, HLA-B-5502, HLA-B-5602, HLA-B15, HLA-B39, HLA-B49, HLA-B50, HLA-B55, HLA-B59, HLA-B61, HLA-Cw, HLA-DRB1

外部ID

HomoloGene：134029 GeneCards：HLA-B

相關疾病

人类免疫缺陷病毒传染性疾病^[1]

基因位置（人类）

染色体	6號染色體^[2]

基因座	6p21.33	起始	31,353,872 bp^[2]
基因座	6p21.33	终止	31,367,067 bp^[2]

RNA表达模式

查阅更多表达数据

基因本體
分子功能	• signaling receptor binding • peptide antigen binding
細胞組分	• integral component of membrane • phagocytic vesicle membrane • 高尔基体 • early endosome membrane • 膜 • Golgi membrane • 细胞膜 • integral component of plasma membrane • cell surface • 内质网 • MHC class I protein complex • ER to Golgi transport vesicle membrane • integral component of lumenal side of endoplasmic reticulum membrane • 外排體 • secretory granule membrane • recycling endosome membrane
生物學過程	• antigen processing and presentation • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • regulation of interleukin-12 production • interferon-gamma-mediated signaling pathway • immune system process • antigen processing and presentation of peptide antigen via MHC class I • regulation of dendritic cell differentiation • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent • protection from natural killer cell mediated cytotoxicity • type I interferon signaling pathway • 免疫反应 • regulation of immune response • regulation of T cell anergy • viral process • regulation of interleukin-6 production • neutrophil degranulation
Sources:Amigo / QuickGO

直系同源

物種

人類

小鼠

Entrez


3106


无数据

Ensembl

ENSG00000228964 ENSG00000234745 ENSG00000206450 ENSG00000224608 ENSG00000223532
ENSG00000232126


无数据

UniProt


P01889


无数据

mRNA序列


NM_005514


无数据

蛋白序列


NP_005505


无数据

基因位置（UCSC）

Chr 6: 31.35 – 31.37 Mb

无数据

PubMed查找

^[3]

无数据

維基數據

檢視/編輯人類

HLA-B是人類白細胞抗原（HLA）的一个基因座，位于6号染色体上。

参考文献

^ 與HLA-B相關的疾病；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000228964、ENSG00000234745、ENSG00000206450、ENSG00000224608、ENSG00000223532、ENSG00000232126 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

延伸阅读

Brown MA, Crane AM, Wordsworth BP. Genetic aspects of susceptibility, severity, and clinical expression in ankylosing spondylitis. Curr Opin Rheumatol. 2002, 14 (4): 354–60. PMID 12118167. doi:10.1097/00002281-200207000-00004.
Carrington M, O'Brien SJ. The influence of HLA genotype on AIDS. Annu Rev Med. 2003, 54: 535–51. PMID 12525683. doi:10.1146/annurev.med.54.101601.152346.
Chung WH, Hung SI, Hong HS, Hsih MS, Yang LC, Ho HC, Wu JY, Chen YT. Medical genetics: a marker for Stevens–Johnson syndrome. Nature. 2004, 428 (6982): 486. Bibcode:2004Natur.428..486C. PMID 15057820. doi:10.1038/428486a.
Colbert RA. The immunobiology of HLA-B27: variations on a theme. Curr Mol Med. 2004, 4 (1): 21–30. PMID 15011956. doi:10.2174/1566524043479293.
Colmegna I, Cuchacovich R, Espinoza LR. HLA-B27-associated reactive arthritis: pathogenetic and clinical considerations. Clin Microbiol Rev. 2004, 17 (2): 348–69. PMC 387405 . PMID 15084505. doi:10.1128/CMR.17.2.348-369.2004. Full text
Cooke GS, Hill AV. Genetics of susceptibility to human infectious disease. Nat Rev Genet. 2001, 2 (12): 967–77. PMID 11733749. doi:10.1038/35103577.
Gao X, Nelson GW, Karacki P, Martin MP, Phair J, Kaslow R, Goedert JJ, Buchbinder S, Hoots K, Vlahov D, O'Brien SJ, Carrington M. Effect of a single amino acid change in MHC class I molecules on the rate of progression to AIDS. N Engl J Med. 2001, 344 (22): 1668–75. PMID 11386265. doi:10.1056/NEJM200105313442203.
Hetherington S, Hughes AR, Mosteller M, Shortino D, Baker KL, Spreen W, Lai E, Davies K, Handley A, Dow DJ, Fling ME, Stocum M, Bowman C, Thurmond LM, Roses AD. Genetic variations in HLA-B region and hypersensitivity reactions to abacavir. Lancet. 2002, 359 (9312): 1121–2. PMID 11943262. doi:10.1016/S0140-6736(02)08158-8.
Hung SI, Chung WH, Liou LB, Chu CC, Lin M, Huang HP, Lin YL, Lan JL, Yang LC, Hong HS, Chen MJ, Lai PC, Wu MS, Chu CY, Wang KH, Chen CH, Fann CS, Wu JY, Chen YT. HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol. Proc Natl Acad Sci USA. 2005, 102 (11): 4134–9. Bibcode:2005PNAS..102.4134H. PMC 554812 . PMID 15743917. doi:10.1073/pnas.0409500102. Full text
Khan MA, Ball EJ. Genetic aspects of ankylosing spondylitis. Best Pract Res Clin Rheumatol. 2002, 16 (4): 675–90. PMID 12406434.
Khan MA. Update on spondyloarthropathies. Ann Intern Med. 2002, 136 (12): 896–907. PMID 12069564. Full text (PDF)（页面存档备份，存于互联网档案馆）
Letvin NL, Walker BD. Immunopathogenesis and immunotherapy in AIDS virus infections. Nat Med. 2003, 9 (7): 861–6. PMID 12835706. doi:10.1038/nm0703-861.
Migueles SA, Sabbaghian MS, Shupert WL, Bettinotti MP, Marincola FM, Martino L, Hallahan CW, Selig SM, Schwartz D, Sullivan J, Connors M. HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors. Proc Natl Acad Sci USA. 2000, 97 (6): 2709–14. Bibcode:2000PNAS...97.2709M. PMC 15994 . PMID 10694578. doi:10.1073/pnas.050567397. Full text（页面存档备份，存于互联网档案馆）
Sheehan NJ. The ramifications of HLA-B27. J R Soc Med. 2004, 97 (1): 10–4. PMC 1079257 . PMID 14702356. doi:10.1258/jrsm.97.1.10.
Tassaneeyakul W, Jantararoungtong T, Chen P, Lin PY, Tiamkao S, Khunarkornsiri U, Chucherd P, Konyoung P, Vannaprasaht S, Choonhakarn C, Pisuttimarn P, Sangviroon A, Tassaneeyakul W. Strong association between HLA-B*5801 and allopurinol-induced Stevens–Johnson syndrome and toxic epidermal necrolysis in a Thai population. Pharmacogenet Genomics. 2009, 19 (9): 704–9. PMID 19696695. doi:10.1097/FPC.0b013e328330a3b8.
Tassaneeyakul W, Tiamkao S, Jantararoungtong T, Chen P, Lin SY, Chen WH, Konyoung P, Khunarkornsiri U, Auvichayapat N, Pavakul K, Kulkantrakorn K, Choonhakarn C, Phonhiamhan S, Piyatrakul N, Aungaree T, Pongpakdee S, Yodnopaglaw P. Association between HLA-B*1502 and carbamazepine–induced severe cutaneous adverse drug reactions in a Thai population. Epilepsia. 2010, 51 (5): 926–30. PMID 20345939. doi:10.1111/j.1528-1167.2010.02533.x. Full text(PDF)（页面存档备份，存于互联网档案馆）

查论编蛋白质数据库图集

Template:PDB Gallery/3106

This article incorporates public domain text from The U.S. National Library of Medicine（页面存档备份，存于互联网档案馆）

外部链接

OMIM 142830
EntrezGene 3106
Template:GeneCard
Nomenclature for factors of the HLA system

表面抗原

主要组织相容性复合体（MHC）
/人類白細胞抗原（HLA）

MHC I	HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G

MHC II	HLA-DM α β HLA-DO α β HLA-DP α1 β1 HLA-DQ α1 α2 β1 β2 β3 HLA-DR α β1 β3 β4 β5 次要组织相容性抗原（英语：Minor histocompatibility antigen）

其它

捕获子（英语：Arrestin）
钙粒蛋白（英语：Calgranulin）
人类血型抗原
细胞粘附分子
分化群

查论编免疫系统索引

描述	生理細胞自體抗原自體抗體補體表面抗原免疫受體（英语：Template:Immunoglobulin superfamily immune receptors）

疾病	過敏（英语：Template:Allergic conditions）缺陷失調過敏和自體免疫疾病腫瘤

治療	程序藥物抗組織胺藥免疫增强剂免疫抑制剂單株抗體（英语：Template:Monoclonals for immune system）