Tyrosine-protein kinase BLK

Protein-coding gene in the species Homo sapiens
BLK
Identifiers
AliasesBLK, MODY11, BLK proto-oncogene, Src family tyrosine kinase
External IDsOMIM: 191305; MGI: 88169; HomoloGene: 1297; GeneCards: BLK; OMA:BLK - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for BLK
Genomic location for BLK
Band8p23.1Start11,486,894 bp[1]
End11,564,599 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for BLK
Genomic location for BLK
Band14 D1|14 33.25 cMStart63,610,285 bp[2]
End63,654,486 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • spleen

  • testicle

  • lymph node

  • granulocyte

  • appendix

  • mucosa of transverse colon

  • bone marrow cells

  • blood

  • tonsil

  • stromal cell of endometrium
Top expressed in
  • spleen

  • mesenteric lymph nodes

  • blood

  • granulocyte

  • thymus

  • subcutaneous adipose tissue

  • bone marrow

  • Ileal epithelium

  • axillary lymph node

  • tunica adventitia of aorta
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • nucleotide binding
  • protein kinase activity
  • non-membrane spanning protein tyrosine kinase activity
  • kinase activity
  • protein binding
  • protein tyrosine kinase activity
  • signaling receptor binding
  • ATP binding
Cellular component
  • membrane
  • extrinsic component of cytoplasmic side of plasma membrane
  • plasma membrane
  • cytosol
Biological process
  • B cell receptor signaling pathway
  • cell differentiation
  • intracellular signal transduction
  • phosphorylation
  • transmembrane receptor protein tyrosine kinase signaling pathway
  • protein phosphorylation
  • regulation of cell population proliferation
  • peptidyl-tyrosine autophosphorylation
  • innate immune response
  • positive regulation of insulin secretion
  • cell migration
  • regulation of B cell receptor signaling pathway
  • peptidyl-tyrosine phosphorylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

640

12143

Ensembl

ENSG00000136573
ENSG00000285369

ENSMUSG00000014453

UniProt

P51451

P16277

RefSeq (mRNA)

NM_001715
NM_001330465

NM_007549

RefSeq (protein)

NP_001317394
NP_001706

NP_031575

Location (UCSC)Chr 8: 11.49 – 11.56 MbChr 14: 63.61 – 63.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tyrosine-protein kinase BLK, also known as B lymphocyte kinase, is a non-receptor tyrosine kinase that in humans is encoded by the BLK gene.[5][6] It is of the Src family of tyrosine kinases.

Interactions

The tyrosine-protein kinase BLK has been shown to interact with UBE3A.[7]

References

  1. ^ a b c ENSG00000285369 GRCh38: Ensembl release 89: ENSG00000136573, ENSG00000285369 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000014453 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Drebin JA, Hartzell SW, Griffin C, Campbell MJ, Niederhuber JE (Mar 1995). "Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk)". Oncogene. 10 (3): 477–86. PMID 7845672.
  6. ^ "Entrez Gene: BLK B lymphoid tyrosine kinase".
  7. ^ Oda H, Kumar S, Howley PM (August 1999). "Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9557–62. Bibcode:1999PNAS...96.9557O. doi:10.1073/pnas.96.17.9557. PMC 22247. PMID 10449731.

Further reading

  • Dymecki SM, Niederhuber JE, Desiderio SV (1990). "Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells". Science. 247 (4940): 332–6. Bibcode:1990Sci...247..332D. doi:10.1126/science.2404338. PMID 2404338.
  • Lin YH, Shin EJ, Campbell MJ, Niederhuber JE (1995). "Transcription of the blk gene in human B lymphocytes is controlled by two promoters". J. Biol. Chem. 270 (43): 25968–75. doi:10.1074/jbc.270.43.25968. PMID 7592787.
  • Saouaf SJ, Kut SA, Fargnoli J, et al. (1995). "Reconstitution of the B cell antigen receptor signaling components in COS cells". J. Biol. Chem. 270 (45): 27072–8. doi:10.1074/jbc.270.45.27072. PMID 7592958.
  • Islam KB, Rabbani H, Larsson C, et al. (1995). "Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk". J. Immunol. 154 (3): 1265–72. doi:10.4049/jimmunol.154.3.1265. PMID 7822795. S2CID 10329710.
  • Donovan JA, Wange RL, Langdon WY, Samelson LE (1994). "The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor". J. Biol. Chem. 269 (37): 22921–4. doi:10.1016/S0021-9258(17)31595-8. PMID 8083187.
  • Pleiman CM, Clark MR, Gauen LK, et al. (1993). "Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase". Mol. Cell. Biol. 13 (9): 5877–87. doi:10.1128/MCB.13.9.5877. PMC 360336. PMID 8395016.
  • Malek SN, Yang CH, Earnshaw WC, et al. (1996). "p150TSP, a conserved nuclear phosphoprotein that contains multiple tetratricopeptide repeats and binds specifically to SH2 domains". J. Biol. Chem. 271 (12): 6952–62. doi:10.1074/jbc.271.12.6952. PMID 8636124.
  • Bewarder N, Weinrich V, Budde P, et al. (1996). "In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation". Mol. Cell. Biol. 16 (9): 4735–43. doi:10.1128/MCB.16.9.4735. PMC 231474. PMID 8756631.
  • Saouaf SJ, Wolven A, Resh MD, Bolen JB (1997). "Palmitylation of Src family tyrosine kinases regulates functional interaction with a B cell substrate". Biochem. Biophys. Res. Commun. 234 (2): 325–9. doi:10.1006/bbrc.1997.6638. PMID 9177269.
  • Hegde R, Srinivasula SM, Ahmad M, et al. (1998). "Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist". J. Biol. Chem. 273 (14): 7783–6. doi:10.1074/jbc.273.14.7783. PMID 9525867.
  • Oda H, Kumar S, Howley PM (1999). "Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9557–62. Bibcode:1999PNAS...96.9557O. doi:10.1073/pnas.96.17.9557. PMC 22247. PMID 10449731.
  • Appel S, Filter M, Reis A, et al. (2002). "Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759". Eur. J. Hum. Genet. 10 (1): 17–25. doi:10.1038/sj.ejhg.5200750. PMID 11896452.
  • Lee S, Ha S, Chung M, et al. (2003). "Mouse DAM1 regulates pro-apoptotic activity of BLK in mammary epithelial cells". Cancer Lett. 188 (1–2): 121–6. doi:10.1016/S0304-3835(02)00055-1. PMID 12406557.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Cho JY, Akbarali Y, Zerbini LF, et al. (2004). "Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene". J. Biol. Chem. 279 (19): 19512–22. doi:10.1074/jbc.M309074200. PMID 14970218.
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