Tilmacoxib
Chemical compound
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Bioavailability | solution (64–88%) compared with capsule (22–40%). |
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Chemical and physical data | |
Formula | C16H19FN2O3S |
Molar mass | 338.40 g·mol−1 |
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Tilmacoxib or JTE-522 is a COX-2 inhibitor and is an effective chemopreventive agent against rat experimental liver fibrosis.[1]
See also
- NS-398
- Celecoxib
References
- ^ Yamamoto H, Kondo M, Nakamori S, Nagano H, Wakasa K, Sugita Y, et al. (August 2003). "JTE-522, a cyclooxygenase-2 inhibitor, is an effective chemopreventive agent against rat experimental liver fibrosis1". Gastroenterology. 125 (2): 556–71. doi:10.1016/s0016-5085(03)00904-1. PMID 12891558.
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Prostanoid signaling modulators
(ligands)
DP (D2)Tooltip Prostaglandin D2 receptor |
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EP (E2)Tooltip Prostaglandin E2 receptor |
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FP (F2α)Tooltip Prostaglandin F receptor |
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IP (I2)Tooltip Prostacyclin receptor |
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TP (TXA2)Tooltip Thromboxane receptor |
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Unsorted |
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(inhibitors)
- Precursors: Linoleic acid
- γ-Linolenic acid (gamolenic acid)
- Dihomo-γ-linolenic acid
- Diacylglycerol
- Arachidonic acid
- Prostaglandin G2
- Prostaglandin H2
- See also
- Receptor/signaling modulators
- Leukotriene signaling modulators
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