TUBG1

Tubulin protein
TUBG1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1Z5V, 1Z5W, 3CB2

Identifiers
AliasesTUBG1, CDCBM4, GCP-1, TUBG, TUBGCP1, tubulin gamma 1
External IDsOMIM: 191135; MGI: 101834; HomoloGene: 833; GeneCards: TUBG1; OMA:TUBG1 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for TUBG1
Genomic location for TUBG1
Band17q21.2Start42,609,641 bp[1]
End42,615,238 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for TUBG1
Genomic location for TUBG1
Band11 D|11 64.24 cMStart101,010,764 bp[2]
End101,017,245 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right testis

  • left testis

  • oocyte

  • gonad

  • gastrocnemius muscle

  • stromal cell of endometrium

  • trabecular bone

  • left ventricle

  • muscle of thigh

  • prefrontal cortex
Top expressed in
  • tail of embryo

  • abdominal wall

  • perirhinal cortex

  • entorhinal cortex

  • otic vesicle

  • yolk sac

  • genital tubercle

  • internal carotid artery

  • CA3 field

  • morula
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • nucleotide binding
  • GTP binding
  • structural constituent of cytoskeleton
  • protein binding
  • GTPase activity
  • identical protein binding
Cellular component
  • cytoplasm
  • ciliary basal body
  • recycling endosome
  • cytosol
  • centrosome
  • pericentriolar material
  • apical part of cell
  • gamma-tubulin complex
  • cilium
  • microtubule organizing center
  • condensed nuclear chromosome
  • spindle microtubule
  • polar microtubule
  • cell leading edge
  • centriole
  • cytoplasmic microtubule
  • microtubule
  • cytoskeleton
  • non-motile cilium
  • nucleus
  • spindle
Biological process
  • meiotic spindle organization
  • G2/M transition of mitotic cell cycle
  • cytoplasmic microtubule organization
  • microtubule-based process
  • microtubule cytoskeleton organization
  • microtubule nucleation
  • ciliary basal body-plasma membrane docking
  • regulation of G2/M transition of mitotic cell cycle
  • mitotic sister chromatid segregation
  • mitotic cell cycle
  • mitotic spindle organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7283

103733

Ensembl

ENSG00000131462

ENSMUSG00000035198

UniProt

P23258

P83887

RefSeq (mRNA)

NM_001070

NM_134024

RefSeq (protein)

NP_001061

NP_598785

Location (UCSC)Chr 17: 42.61 – 42.62 MbChr 11: 101.01 – 101.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tubulin, gamma 1 is a protein in humans that is encoded by the TUBG1 gene.[5] This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000131462 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035198 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Tubulin, gamma 1".

Further reading

  • Zhang X, Chen Q, Feng J, Hou J, Yang F, Liu J, Jiang Q, Zhang C (July 2009). "Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome". Journal of Cell Science. 122 (Pt 13): 2240–51. doi:10.1242/jcs.042747. PMID 19509060.
  • Lau AS, Mruk DD (April 2003). "Rab8B GTPase and junction dynamics in the testis". Endocrinology. 144 (4): 1549–63. doi:10.1210/en.2002-220893. PMID 12639940.
  • Feng Y, Olson EC, Stukenberg PT, Flanagan LA, Kirschner MW, Walsh CA (December 2000). "LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome". Neuron. 28 (3): 665–79. doi:10.1016/S0896-6273(00)00145-8. PMID 11163258. S2CID 15923472.
  • Hsu LC, White RL (October 1998). "BRCA1 is associated with the centrosome during mitosis". Proceedings of the National Academy of Sciences of the United States of America. 95 (22): 12983–8. doi:10.1073/pnas.95.22.12983. PMC 23679. PMID 9789027.
  • Manning JA, Shalini S, Risk JM, Day CL, Kumar S (March 2010). Hotchin NA (ed.). "A direct interaction with NEDD1 regulates gamma-tubulin recruitment to the centrosome". PLOS ONE. 5 (3): e9618. doi:10.1371/journal.pone.0009618. PMC 2835750. PMID 20224777.
  • Aldaz H, Rice LM, Stearns T, Agard DA (May 2005). "Insights into microtubule nucleation from the crystal structure of human gamma-tubulin". Nature. 435 (7041): 523–7. doi:10.1038/nature03586. PMID 15917813. S2CID 4388646.
  • Niu Y, Liu T, Tse GM, Sun B, Niu R, Li HM, Wang H, Yang Y, Ye X, Wang Y, Yu Q, Zhang F (April 2009). "Increased expression of centrosomal alpha, gamma-tubulin in atypical ductal hyperplasia and carcinoma of the breast". Cancer Science. 100 (4): 580–7. doi:10.1111/j.1349-7006.2008.01075.x. PMID 19215229. S2CID 205234685.
  • Hampe C, Ardila-Osorio H, Fournier M, Brice A, Corti O (July 2006). "Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity". Human Molecular Genetics. 15 (13): 2059–75. doi:10.1093/hmg/ddl131. PMID 16714300.
  • Zyss D, Montcourrier P, Vidal B, Anguille C, Mérezègue F, Sahuquet A, Mangeat PH, Coopman PJ (December 2005). "The Syk tyrosine kinase localizes to the centrosomes and negatively affects mitotic progression". Cancer Research. 65 (23): 10872–80. doi:10.1158/0008-5472.CAN-05-1270. PMID 16322234.


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