TMX1

Protein-coding gene in the species Homo sapiens
TMX1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1X5E

Identifiers
AliasesTMX1, PDIA11, TMX, TXNDC, TXNDC1, thioredoxin related transmembrane protein 1
External IDsOMIM: 610527; MGI: 1919986; HomoloGene: 12482; GeneCards: TMX1; OMA:TMX1 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for TMX1
Genomic location for TMX1
Band14q22.1Start51,240,162 bp[1]
End51,257,655 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for TMX1
Genomic location for TMX1
Band12|12 C2Start70,499,869 bp[2]
End70,514,814 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tibia

  • skin of hip

  • mucosa of sigmoid colon

  • germinal epithelium

  • trabecular bone

  • oral cavity

  • skin of thigh

  • jejunal mucosa

  • superficial temporal artery

  • secondary oocyte
Top expressed in
  • retinal pigment epithelium

  • cumulus cell

  • ciliary body

  • epithelium of lens

  • Paneth cell

  • fossa

  • condyle

  • Epithelium of choroid plexus

  • aortic valve

  • supraoptic nucleus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • disulfide oxidoreductase activity
  • protein disulfide isomerase activity
Cellular component
  • integral component of membrane
  • membrane
  • endoplasmic reticulum membrane
  • endoplasmic reticulum
Biological process
  • protein folding
  • response to endoplasmic reticulum stress
  • cell redox homeostasis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

81542

72736

Ensembl

ENSG00000139921

ENSMUSG00000021072

UniProt

Q9H3N1

Q8VBT0

RefSeq (mRNA)

NM_030755

NM_028339

RefSeq (protein)

NP_110382

NP_082615

Location (UCSC)Chr 14: 51.24 – 51.26 MbChr 12: 70.5 – 70.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Thioredoxin-related transmembrane protein 1 is a protein that in humans is encoded by the TMX1 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000139921 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021072 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Matsuo Y, Akiyama N, Nakamura H, Yodoi J, Noda M, Kizaka-Kondoh S (Mar 2001). "Identification of a novel thioredoxin-related transmembrane protein" (PDF). J Biol Chem. 276 (13): 10032–8. doi:10.1074/jbc.M011037200. PMID 11152479.
  6. ^ "Entrez Gene: TXNDC1 thioredoxin domain containing 1".

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. Bibcode:2003Natur.421..601H. doi:10.1038/nature01348. PMID 12508121.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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  • 1x5e: The solution structure of the thioredoxin-like domain of human Thioredoxin-related transmembrane protein
    1x5e: The solution structure of the thioredoxin-like domain of human Thioredoxin-related transmembrane protein
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TXNDC human genes


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