SPC24

Protein-coding gene in the species Homo sapiens
SPC24
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2VE7, 3IZ0

Identifiers
AliasesSPC24, SPBC24, NDC80 kinetochore complex component, SPC24 component of NDC80 kinetochore complex
External IDsOMIM: 609394; MGI: 1914879; HomoloGene: 12166; GeneCards: SPC24; OMA:SPC24 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for SPC24
Genomic location for SPC24
Band19p13.2Start11,131,520 bp[1]
End11,155,808 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for SPC24
Genomic location for SPC24
Band9|9 A3Start21,666,738 bp[2]
End21,671,599 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ventricular zone

  • ganglionic eminence

  • stromal cell of endometrium

  • trabecular bone

  • testicle

  • bone marrow

  • gonad

  • mucosa of transverse colon

  • bone marrow cells

  • appendix
Top expressed in
  • hand

  • yolk sac

  • embryo

  • embryo

  • epiblast

  • ventricular zone

  • thymus

  • morula

  • primitive streak

  • Paneth cell
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
Cellular component
  • cytosol
  • Ndc80 complex
  • nucleolus
  • chromosome, centromeric region
  • nucleus
  • kinetochore
  • chromosome
Biological process
  • cell division
  • cell cycle
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

147841

67629

Ensembl

ENSG00000161888

ENSMUSG00000074476

UniProt

Q8NBT2

Q9D083

RefSeq (mRNA)

NM_182513
NM_001317031
NM_001317032
NM_001317033

NM_026282
NM_001357331

RefSeq (protein)

NP_001303960
NP_001303961
NP_001303962
NP_872319

NP_080558
NP_001344260

Location (UCSC)Chr 19: 11.13 – 11.16 MbChr 9: 21.67 – 21.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kinetochore protein Spc24 is a protein that in humans is encoded by the SPC24 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000161888 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074476 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: SPC24 SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)".

Further reading

  • Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Ahonen LJ, Kallio MJ, Daum JR, Bolton M, Manke IA, Yaffe MB, Stukenberg PT, Gorbsky GJ (June 2005). "Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores". Current Biology. 15 (12): 1078–89. doi:10.1016/j.cub.2005.05.026. PMID 15964272. S2CID 14251198.
  • Ciferri C, De Luca J, Monzani S, Ferrari KJ, Ristic D, Wyman C, Stark H, Kilmartin J, Salmon ED, Musacchio A (August 2005). "Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore". The Journal of Biological Chemistry. 280 (32): 29088–95. doi:10.1074/jbc.M504070200. PMID 15961401.
  • Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (September 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.
  • McCleland ML, Kallio MJ, Barrett-Wilt GA, Kestner CA, Shabanowitz J, Hunt DF, Gorbsky GJ, Stukenberg PT (January 2004). "The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment". Current Biology. 14 (2): 131–7. doi:10.1016/j.cub.2003.12.058. PMID 14738735. S2CID 16533093.
  • Bharadwaj R, Qi W, Yu H (March 2004). "Identification of two novel components of the human NDC80 kinetochore complex". The Journal of Biological Chemistry. 279 (13): 13076–85. doi:10.1074/jbc.M310224200. PMID 14699129.
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