SDF4

Protein-coding gene in the species Homo sapiens
SDF4
Identifiers
AliasesSDF4, Cab45, SDF-4, stromal cell derived factor 4
External IDsOMIM: 614282; MGI: 108079; HomoloGene: 32121; GeneCards: SDF4; OMA:SDF4 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for SDF4
Genomic location for SDF4
Band1p36.33Start1,216,909 bp[1]
End1,232,067 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for SDF4
Genomic location for SDF4
Band4|4 E2Start156,077,329 bp[2]
End156,098,067 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • stromal cell of endometrium

  • right hemisphere of cerebellum

  • cartilage tissue

  • mucosa of transverse colon

  • thoracic aorta

  • ascending aorta

  • Descending thoracic aorta

  • right auricle

  • cardia

  • right coronary artery
Top expressed in
  • stroma of bone marrow

  • molar

  • supraoptic nucleus

  • dentate gyrus of hippocampal formation granule cell

  • spermatocyte

  • mesenteric lymph nodes

  • calvaria

  • right lung lobe

  • duodenum

  • superior frontal gyrus
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • metal ion binding
  • identical protein binding
  • calcium ion binding
Cellular component
  • cell projection
  • extracellular exosome
  • bleb
  • late endosome
  • Golgi lumen
  • cytoplasm
  • membrane
  • plasma membrane
  • Golgi apparatus
  • endoplasmic reticulum
Biological process
  • UV protection
  • zymogen granule exocytosis
  • response to ethanol
  • cerebellum development
  • calcium-ion regulated exocytosis
  • exocytosis
  • fat cell differentiation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51150

20318

Ensembl

ENSG00000078808

ENSMUSG00000029076

UniProt

Q9BRK5

Q61112

RefSeq (mRNA)

NM_016176
NM_016547

NM_011341
NM_001302467
NM_001302468
NM_001302469

RefSeq (protein)

NP_057260
NP_057631

NP_001289396
NP_001289397
NP_001289398
NP_035471

Location (UCSC)Chr 1: 1.22 – 1.23 MbChr 4: 156.08 – 156.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

45 kDa calcium-binding protein is a protein that in humans is encoded by the SDF4 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000078808 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029076 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Koivu T, Laitinen S, Riento K, Olkkonen VM (Sep 1997). "Sequence of a human cDNA encoding Cab45, a Ca2+-binding protein with six EF-hand motifs". DNA Seq. 7 (3–4): 217–20. doi:10.3109/10425179709034038. PMID 9254016.
  6. ^ Scherer PE, Lederkremer GZ, Williams S, Fogliano M, Baldini G, Lodish HF (May 1996). "Cab45, a novel (Ca2+)-binding protein localized to the Golgi lumen". J Cell Biol. 133 (2): 257–68. doi:10.1083/jcb.133.2.257. PMC 2120788. PMID 8609160.
  7. ^ "Entrez Gene: SDF4 stromal cell derived factor 4".

Further reading

  • Honoré B, Vorum H (2000). "The CREC family, a novel family of multiple EF-hand, low-affinity Ca(2+)-binding proteins localised to the secretory pathway of mammalian cells". FEBS Lett. 466 (1): 11–8. doi:10.1016/S0014-5793(99)01780-9. PMID 10648803.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
  • Lam PP, Hyvärinen K, Kauppi M, et al. (2007). "A cytosolic splice variant of Cab45 interacts with Munc18b and impacts on amylase secretion by pancreatic acini". Mol. Biol. Cell. 18 (7): 2473–80. doi:10.1091/mbc.E06-10-0950. PMC 1924827. PMID 17442889.


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