Protein-coding gene in humans
| DYNLT3 |
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| Identifiers |
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| Aliases | DYNLT3, RP3, TCTE1L, TCTEX1L, dynein light chain Tctex-type 3 |
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| External IDs | OMIM: 300302; MGI: 1914367; HomoloGene: 21304; GeneCards: DYNLT3; OMA:DYNLT3 - orthologs |
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| Gene location (Human) |
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 | | Chr. | X chromosome (human)[1] |
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| | Band | Xp11.4 | Start | 37,836,757 bp[1] |
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| End | 37,847,571 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | X chromosome (mouse)[2] |
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| | Band | X|X A1.1 | Start | 9,520,506 bp[2] |
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| End | 9,529,242 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - gums
- gingival epithelium
- pons
- dorsal motor nucleus of vagus nerve
- Pars compacta
- Brodmann area 23
- lateral nuclear group of thalamus
- optic nerve
- oral cavity
- glomerulus
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| | Top expressed in | - Epithelium of choroid plexus
- transitional epithelium of urinary bladder
- seminal vesicula
- deep cerebellar nuclei
- medial vestibular nucleus
- retinal pigment epithelium
- lateral geniculate nucleus
- epithelium of lens
- conjunctival fornix
- facial motor nucleus
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| | More reference expression data |
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| BioGPS |  | | More reference expression data |
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| Gene ontology |
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| Molecular function | - cytoskeletal motor activity
- protein binding
- identical protein binding
| | Cellular component | - cytoplasm
- kinetochore
- chromosome
- dynein complex
- cytoplasmic dynein complex
- microtubule
- chromosome, centromeric region
- cytoskeleton
- nucleus
- mitotic spindle astral microtubule
| | Biological process | - cell cycle
- regulation of mitotic cell cycle
- cell division
- positive regulation of mitotic cell cycle
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr X: 37.84 – 37.85 Mb | Chr X: 9.52 – 9.53 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Dynein, light chain, Tctex-type 3, also known as DYNLT3, is a protein which in humans is encoded by the DYNLT3 gene.[5][6]
Function
DYNLT3 is a member of the dynein motor protein family. DYNLT3 binds to BUB3, a spindle checkpoint protein is present on kinetochores at prometaphase.[7] DYNLT3 can also function as a transcription regulator of Bcl-2 gene through binding to SATB1 in a dynein-independent manner.[8]
Interactions
DYNLT3 has been shown to interact with VDAC1.[9]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000165169 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031176 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: DYNLT3 dynein, light chain, Tctex-type 3".
- ^ Roux AF, Rommens J, McDowell C, Anson-Cartwright L, Bell S, Schappert K, Fishman GA, Musarella M (February 1994). "Identification of a gene from Xp21 with similarity to the tctex-1 gene of the murine t complex". Hum. Mol. Genet. 3 (2): 257–63. doi:10.1093/hmg/3.2.257. PMID 8004092.
- ^ Lo KW, Kogoy JM, Pfister KK (April 2007). "The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3". J. Biol. Chem. 282 (15): 11205–12. doi:10.1074/jbc.M611279200. PMID 17289665.
- ^ Yeh TY, Chuang JZ, Sung CH (August 2005). "Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway". J. Cell Sci. 118 (Pt 15): 3431–43. doi:10.1242/jcs.02472. PMID 16079286.
- ^ Schwarzer, Christian; Barnikol-Watanabe Shitsu; Thinnes Friedrich P; Hilschmann Norbert (Sep 2002). "Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74". Int. J. Biochem. Cell Biol. 34 (9): 1059–70. doi:10.1016/S1357-2725(02)00026-2. ISSN 1357-2725. PMID 12009301. S2CID 11632830.
Further reading
- Roux AF, Rommens J, McDowell C, et al. (1994). "Identification of a gene from Xp21 with similarity to the tctex-1 gene of the murine t complex". Hum. Mol. Genet. 3 (2): 257–63. doi:10.1093/hmg/3.2.257. PMID 8004092.
- Bauch A, Campbell KS, Reth M (1998). "Interaction of the CD5 cytoplasmic domain with the Ca2+/calmodulin-dependent kinase IIdelta". Eur. J. Immunol. 28 (7): 2167–77. doi:10.1002/(SICI)1521-4141(199807)28:07<2167::AID-IMMU2167>3.0.CO;2-L. PMID 9692886. S2CID 21656634.
- Mueller S, Cao X, Welker R, Wimmer E (2002). "Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis". J. Biol. Chem. 277 (10): 7897–904. doi:10.1074/jbc.M111937200. PMID 11751937.
- Schwarzer C, Barnikol-Watanabe S, Thinnes FP, Hilschmann N (2002). "Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74". Int. J. Biochem. Cell Biol. 34 (9): 1059–70. doi:10.1016/S1357-2725(02)00026-2. PMID 12009301. S2CID 11632830.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Douglas MW, Diefenbach RJ, Homa FL, et al. (2004). "Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport". J. Biol. Chem. 279 (27): 28522–30. doi:10.1074/jbc.M311671200. PMID 15117959.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Yeh TY, Chuang JZ, Sung CH (2005). "Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway". J. Cell Sci. 118 (Pt 15): 3431–43. doi:10.1242/jcs.02472. PMID 16079286.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- O'Rourke SM, Dorfman MD, Carter JC, Bowerman B (2007). "Dynein modifiers in C. elegans: light chains suppress conditional heavy chain mutants". PLOS Genet. 3 (8): e128. doi:10.1371/journal.pgen.0030128. PMC 1937013. PMID 17676955.
