Clocinnamox
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Preferred IUPAC name (2E)-3-(4-Chlorophenyl)-N-[(4R,4aS,7aR,12bR)-3-(cyclopropylmethyl)-9-hydroxy-7-oxo-1,2,3,4,5,6,7,7a-octahydro-4aH-4,12-methano[1]benzofuro[3,2-e]isoquinolin-4a-yl]prop-2-enamide | |
Other names Chlorocinnamoylaminodihydronormorphinone | |
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Properties | |
Chemical formula | C29H29ClN2O4 |
Molar mass | 505.01 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references |
Chemical compound
Clocinnamox is a selective, irreversible μ-opioid receptor antagonist.[1]
References
- ^ Filho, CB; Del Fabbro, L; De Gomes, MG; Goes, AT; Souza, LC; Boeira, SP; Jesse, CR (2013). "Kappa-opioid receptors mediate the antidepressant-like activity of hesperidin in the mouse forced swimming test". European Journal of Pharmacology. 698 (1–3): 286–91. doi:10.1016/j.ejphar.2012.11.003. PMID 23178563.
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Opioid receptor modulators
(MOR)
(DOR)
(KOR)
(NOP)
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Antagonists |
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- Enkephalinase inhibitors: Amastatin
- BL-2401
- Candoxatril
- D -Phenylalanine
- Dexecadotril (retorphan)
- Ecadotril (sinorphan)
- Kelatorphan
- Racecadotril (acetorphan)
- RB-101
- RB-120
- RB-3007
- Opiorphan
- Selank
- Semax
- Spinorphin
- Thiorphan
- Tynorphin
- Ubenimex (bestatin)
- Propeptides: β-Lipotropin (proendorphin)
- Prodynorphin
- Proenkephalin
- Pronociceptin
- Proopiomelanocortin (POMC)
- Others: Kyotorphin (met-enkephalin releaser/degradation stabilizer)
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