Class II PI 3-kinases
Class II PI 3-kinases are a subgroup of the enzyme family, phosphoinositide 3-kinase that share a common protein domain structure, substrate specificity and method of activation.
Class II PI 3-kinases were the most recently identified class of PI 3-kinases.
There are three class II PI 3-kinase isoforms expressed in mammalian cells;
- PI3K-C2α encoded by the PIK3C2A gene
- PI3K-C2β encoded by the PIK3C2B gene
- PI3K-C2γ encoded by the PIK3C2G gene
See also
- Phosphoinositide 3-kinase
References
- Stein RC (September 2001). "Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment". Endocrine-Related Cancer. 8 (3): 237–248. doi:10.1677/erc.0.0080237. PMID 11566615.
- Foster FM, Traer CJ, Abraham SM, Fry MJ (August 2003). "The phosphoinositide (PI) 3-kinase family". Journal of Cell Science. 116 (Pt 15): 3037–3040. doi:10.1242/jcs.00609. PMID 12829733.
- Vanhaesebroeck B, Waterfield MD (November 1999). "Signaling by distinct classes of phosphoinositide 3-kinases". Experimental Cell Research. 253 (1): 239–254. doi:10.1006/excr.1999.4701. PMID 10579926.
- v
- t
- e
Transferases: phosphorus-containing groups (EC 2.7)
phosphotransferase/kinase
(PO4)
2.7.1: OH acceptor |
|
---|---|
2.7.2: COOH acceptor | |
2.7.3: N acceptor | |
2.7.4: PO4 acceptor |
(P2O7)
(PO4-nucleoside)
Polymerase |
| ||||
---|---|---|---|---|---|
Phosphorolytic 3' to 5' exoribonuclease | |||||
Nucleotidyltransferase | |||||
Guanylyltransferase | |||||
Other |
Phosphatidyltransferases | |
---|---|
Glycosyl-1-phosphotransferase |
(PO4; protein acceptor)
2.7.10: protein-tyrosine |
|
---|---|
2.7.11: protein-serine/threonine |
|
2.7.12: protein-dual-specificity |
|
2.7.13: protein-histidine |
This cell biology article is a stub. You can help Wikipedia by expanding it. |
- v
- t
- e