CTEP
Chemical compound
Identifiers | |
---|---|
| |
CAS Number |
|
PubChem CID |
|
IUPHAR/BPS |
|
ChemSpider |
|
UNII |
|
CompTox Dashboard (EPA) |
|
Chemical and physical data | |
Formula | C19H13ClF3N3O |
Molar mass | 391.78 g·mol−1 |
3D model (JSmol) |
|
| |
InChI
|
CTEP (Ro4956371) is a research drug developed by Hoffmann-La Roche that acts as a selective allosteric antagonist of the metabotropic glutamate receptor subtype mGluR5, binding with nanomolar affinity and over 1000 times selectivity over all other receptor targets tested. In animal studies it was found to have a high oral bioavailability and a long duration of action, lasting 18 hours after a single dose, giving it considerably improved properties over older mGluR5 antagonists such as MPEP and fenobam.[1]
References
- ^ Lindemann L, Jaeschke G, Michalon A, Vieira E, Honer M, Spooren W, Porter R, Hartung T, Kolczewski S, Büttelmann B, Flament C, Diener C, Fischer C, Gatti S, Prinssen EP, Parrott N, Hoffmann G, Wettstein JG (November 2011). "CTEP: a novel, potent, long-acting, and orally bioavailable metabotropic glutamate receptor 5 inhibitor". The Journal of Pharmacology and Experimental Therapeutics. 339 (2): 474–86. doi:10.1124/jpet.111.185660. PMID 21849627. S2CID 2554923.
- v
- t
- e
Metabotropic glutamate receptor modulators
mGluR1Tooltip Metabotropic glutamate receptor 1 |
|
---|---|
mGluR5Tooltip Metabotropic glutamate receptor 5 |
|
mGluR2Tooltip Metabotropic glutamate receptor 2 |
|
---|---|
mGluR3Tooltip Metabotropic glutamate receptor 3 |
|
mGluR4Tooltip Metabotropic glutamate receptor 4 |
|
---|---|
mGluR6Tooltip Metabotropic glutamate receptor 6 |
|
mGluR7Tooltip Metabotropic glutamate receptor 7 | |
mGluR8Tooltip Metabotropic glutamate receptor 8 |
|
See also: Receptor/signaling modulators • Ionotropic glutamate receptor modulators • Glutamate metabolism/transport modulators
This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it. |
- v
- t
- e